Case Report of a Poorly Differentiated Uterine Tumour with t(10;17) Trans location and Neuroectodermal Phenotype

Frédéric Amant; Thomas Tousseyn; Lieve Coenegrachts; Jan Decloedt; Philippe Moerman; Maria Debiec-Rychter

Case Report of a Poorly Differentiated Uterine Tumour with t(10;17) Trans location and Neuroectodermal Phenotype

Frédéric Amant, Thomas Tousseyn, Lieve Coenegrachts, Jan Decloedt, Philippe Moerman, Maria Debiec-Rychter

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Abstract

Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO)2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing's sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report

Original language	English
Pages (from-to)	2367-2371
Journal	Anticancer research
Volume	31
Issue number	6
Publication status	Published - 2011

Cite this

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title = "Case Report of a Poorly Differentiated Uterine Tumour with t(10;17) Trans location and Neuroectodermal Phenotype",

abstract = "Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO)2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing's sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report",

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T1 - Case Report of a Poorly Differentiated Uterine Tumour with t(10;17) Trans location and Neuroectodermal Phenotype

AU - Amant, Frédéric

AU - Tousseyn, Thomas

AU - Coenegrachts, Lieve

AU - Decloedt, Jan

AU - Moerman, Philippe

AU - Debiec-Rychter, Maria

PY - 2011

Y1 - 2011

N2 - Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO)2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing's sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report

AB - Endometrial stromal sarcoma (ESS) with primitive neuroectodermal differentiation is a very uncommon entity. Such a case presenting as stage IIIc (International Federation of Gynaecology and Obstetrics (FIGO)2010) disease in a 51-year-old female is described. Microscopy suggested a small blue round cell tumour. Cytogenetic and multicolour fluorescent in situ hybridisation (M-FISH) analysis revealed a complex karyotype with the presence of unbalanced t(10;17)(q22;p13) translocation, indicating ESS. Peripheral Ewing's sarcoma was excluded based on FISH and RT-PCR fusion transcripts analysis. After surgical staging, the patient received bleomycin-etoposide-cisplatin combination chemotherapy. A detailed analysis of the histopathology and genetic findings forms the basis of this report

M3 - Article

C2 - 21737666

SN - 0250-7005

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EP - 2371

JO - Anticancer research

JF - Anticancer research

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