TY - JOUR
T1 - Cell-Derived Microparticles in the Pathogenesis of Cardiovascular Disease Friend or Foe?
AU - Tushuizen, Maarten E.
AU - Diamant, Michaela
AU - Sturk, Augueste
AU - Nieuwland, Rienk
PY - 2011
Y1 - 2011
N2 - Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be involved in the maintenance and preservation of cellular homeostasis and in promoting defense mechanisms. Here, we summarize recent studies revealing these 2 faces of microparticles in cardiovascular disease. (Arterioscler Thromb Vasc Biol. 2011;31:4-9.)
AB - Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be involved in the maintenance and preservation of cellular homeostasis and in promoting defense mechanisms. Here, we summarize recent studies revealing these 2 faces of microparticles in cardiovascular disease. (Arterioscler Thromb Vasc Biol. 2011;31:4-9.)
U2 - https://doi.org/10.1161/ATVBAHA.109.200998
DO - https://doi.org/10.1161/ATVBAHA.109.200998
M3 - Article
C2 - 21160062
SN - 1079-5642
VL - 31
SP - 4
EP - 9
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 1
ER -