TY - JOUR
T1 - Cell Therapy in Reperfused Acute Myocardial Infarction Does Not Improve the Recovery of Perfusion in the Infarcted Myocardium: A Cardiac MR Imaging Study
AU - Robbers, Lourens F. H. J.
AU - Nijveldt, Robin
AU - Beek, Aernout M.
AU - Hirsch, Alexander
AU - van der Laan, Anja M.
AU - van der Vleuten, Pieter A.
AU - Tio, René A.
AU - Tijssen, Jan G. P.
AU - Hofman, Mark B. M.
AU - Piek, Jan J.
AU - Zijlstra, Felix
AU - van Rossum, Albert C.
AU - Delewi, R.
PY - 2014
Y1 - 2014
N2 - Purpose: To investigate the effects of cell therapy on myocardial perfusion recovery after treatment of acute myocardial infarction (MI) with primary percutaneous coronary intervention (PCI). Materials and Methods: In this HEBE trial substudy, which was approved by the institutional review board (trial registry number IS-RCTN95796863), the authors assessed the effects of intra-coronary infusion with bone marrow-derived mononuclear cells (BMMCs) or peripheral blood-derived mononuclear cells (PBMCs) on myocardial perfusion recovery by using cardiac magnetic resonance (MR) imaging after revascularization. In 152 patients with acute MI treated with PCI, cardiac MR imaging was performed after obtaining informed consent-before randomization to BMMC, PBMC, or standard therapy (control group)-and repeated at 4-month follow-up. Cardiac MR imaging consisted of cine, rest first-pass perfusion, and late gadolinium enhancement imaging. Perfusion was evaluated semiquantitatively with signal intensity-time curves by calculating the relative upslope (percentage signal intensity change). The relative upslope was calculated for the MI core, adjacent border zone, and remote myocardium. Perfusion differences among treatment groups or between baseline and follow-up were assessed with the Wilcoxon signed rank or Mann-Whitney U test. Results: At baseline, myocardial perfusion differed between the MI core (median, 6.0%; interquartile range [IQR], 4.1%-8.0%), border zone (median, 8.4%; IQR, 6.4%-10.2%), and remote myocardium (median, 12.2%; IQR, 10.5%-15.9%) (P <.001 for all), with equal distribution among treatment groups. These interregional differences persisted at follow-up (P <.001 for all). No difference in perfusion recovery was found between the three treatment groups for any region. Conclusion: After revascularization of ST-elevation MI, cell therapy does not augment the recovery of resting perfusion in either the MI core or border zone. (C) RSNA, 2014
AB - Purpose: To investigate the effects of cell therapy on myocardial perfusion recovery after treatment of acute myocardial infarction (MI) with primary percutaneous coronary intervention (PCI). Materials and Methods: In this HEBE trial substudy, which was approved by the institutional review board (trial registry number IS-RCTN95796863), the authors assessed the effects of intra-coronary infusion with bone marrow-derived mononuclear cells (BMMCs) or peripheral blood-derived mononuclear cells (PBMCs) on myocardial perfusion recovery by using cardiac magnetic resonance (MR) imaging after revascularization. In 152 patients with acute MI treated with PCI, cardiac MR imaging was performed after obtaining informed consent-before randomization to BMMC, PBMC, or standard therapy (control group)-and repeated at 4-month follow-up. Cardiac MR imaging consisted of cine, rest first-pass perfusion, and late gadolinium enhancement imaging. Perfusion was evaluated semiquantitatively with signal intensity-time curves by calculating the relative upslope (percentage signal intensity change). The relative upslope was calculated for the MI core, adjacent border zone, and remote myocardium. Perfusion differences among treatment groups or between baseline and follow-up were assessed with the Wilcoxon signed rank or Mann-Whitney U test. Results: At baseline, myocardial perfusion differed between the MI core (median, 6.0%; interquartile range [IQR], 4.1%-8.0%), border zone (median, 8.4%; IQR, 6.4%-10.2%), and remote myocardium (median, 12.2%; IQR, 10.5%-15.9%) (P <.001 for all), with equal distribution among treatment groups. These interregional differences persisted at follow-up (P <.001 for all). No difference in perfusion recovery was found between the three treatment groups for any region. Conclusion: After revascularization of ST-elevation MI, cell therapy does not augment the recovery of resting perfusion in either the MI core or border zone. (C) RSNA, 2014
U2 - https://doi.org/10.1148/radiol.14131121
DO - https://doi.org/10.1148/radiol.14131121
M3 - Article
C2 - 24617731
SN - 0033-8419
VL - 272
SP - 113
EP - 122
JO - Radiology
JF - Radiology
IS - 1
ER -