TY - JOUR
T1 - Central congenital hypothyroidism due to gestational hyperthyroidism: Detection where prevention failed
AU - Kempers, Marlies J. E.
AU - van Tijn, David A.
AU - van Trotsenburg, A. S. Paul
AU - de Vijlder, Jan J. M.
AU - Wiedijk, Brenda M.
AU - Vulsma, Thomas
PY - 2003
Y1 - 2003
N2 - Much worldwide attention is given to the adverse effects of maternal Graves' disease on the fetal and neonatal thyroid and its function. However, reports concerning the adverse effects of maternal Graves' disease on the pituitary function, illustrated by the development of central congenital hypothyroidism (CCH) in the offspring of these mothers, are scarce. We studied thyroid hormone determinants of 18 children with CCH born to mothers with Graves' disease. Nine mothers were diagnosed after pregnancy, the majority after their children were detected with CCH by neonatal screening. Four mothers were diagnosed during pregnancy and treated with antithyroid drugs since diagnosis. Another four mothers were diagnosed before pregnancy, but they used antithyroid drugs irregularly; free T-4 concentrations less than 1.7 ng/dl ( <22 pmol/ liter) were not encountered during pregnancy. All neonates had decreased plasma free T-4 concentrations (range 0.3 - 0.9 ng/dl, 3.9 - 11.5 pmol/liter); plasma TSH ranged between 0.1 and 6.6 mU/liter. TRH tests showed pituitary dysfunction. Seventeen children needed T-4 supplementation. Because all mothers were insufficiently treated during pregnancy, it is hypothesized that a hyperthyroid fetal environment impaired maturation of the fetal hypothalamic-pituitary-thyroid system. The frequent occurrence of this type of CCH ( estimated incidence 1: 35,000) warrants early detection and treatment to minimize the risk of cerebral damage. A T-4-based screening program appears useful in detecting this type of CCH. However, the preferential and presumably best strategy to prevent CCH caused by maternal Graves' disease is preserving euthyroidism throughout pregnancy
AB - Much worldwide attention is given to the adverse effects of maternal Graves' disease on the fetal and neonatal thyroid and its function. However, reports concerning the adverse effects of maternal Graves' disease on the pituitary function, illustrated by the development of central congenital hypothyroidism (CCH) in the offspring of these mothers, are scarce. We studied thyroid hormone determinants of 18 children with CCH born to mothers with Graves' disease. Nine mothers were diagnosed after pregnancy, the majority after their children were detected with CCH by neonatal screening. Four mothers were diagnosed during pregnancy and treated with antithyroid drugs since diagnosis. Another four mothers were diagnosed before pregnancy, but they used antithyroid drugs irregularly; free T-4 concentrations less than 1.7 ng/dl ( <22 pmol/ liter) were not encountered during pregnancy. All neonates had decreased plasma free T-4 concentrations (range 0.3 - 0.9 ng/dl, 3.9 - 11.5 pmol/liter); plasma TSH ranged between 0.1 and 6.6 mU/liter. TRH tests showed pituitary dysfunction. Seventeen children needed T-4 supplementation. Because all mothers were insufficiently treated during pregnancy, it is hypothesized that a hyperthyroid fetal environment impaired maturation of the fetal hypothalamic-pituitary-thyroid system. The frequent occurrence of this type of CCH ( estimated incidence 1: 35,000) warrants early detection and treatment to minimize the risk of cerebral damage. A T-4-based screening program appears useful in detecting this type of CCH. However, the preferential and presumably best strategy to prevent CCH caused by maternal Graves' disease is preserving euthyroidism throughout pregnancy
U2 - https://doi.org/10.1210/jc.2003-030665
DO - https://doi.org/10.1210/jc.2003-030665
M3 - Article
C2 - 14671180
SN - 0021-972X
VL - 88
SP - 5851
EP - 5857
JO - Journal of clinical endocrinology and metabolism
JF - Journal of clinical endocrinology and metabolism
IS - 12
ER -