Central nervous system reactivation of herpesviridae family in patients with COVID-19

Mahboubeh Haddad; Fereshte Sheybani; Nahid Olfati; Mohammad Ali Nahayati; Reza Boostani; Parvaneh Layegh; Azra Rashid-Nejad

doi:https://doi.org/10.1007/s13365-023-01132-4

Central nervous system reactivation of herpesviridae family in patients with COVID-19

Mahboubeh Haddad, Fereshte Sheybani, Nahid Olfati, Mohammad Ali Nahayati, Reza Boostani, Parvaneh Layegh, Azra Rashid-Nejad

Doctoral School

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

The objective of this study is to describe our COVID-19 patients with herpesviridae reactivation in the central nervous system (CNS). Four patients were described including two with acute encephalitis and two with acute encephalomyelitis. Three of four patients had abnormal findings on neuroimaging studies. One of four patients died, one survived with major neurological sequelae, and two others fully recovered. Herpesviridae reactivation in the CNS in patients with COVID-19 is a rare but serious coincidence. The optimal therapeutic management has not been investigated and until more information is available, it is prudent to treat these patients with appropriate antivirals with or without anti-inflammatory agents.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	JOURNAL OF NEUROVIROLOGY
Volume	29
Issue number	2
Early online date	2023
DOIs	https://doi.org/10.1007/s13365-023-01132-4
Publication status	Published - Apr 2023

Keywords

COVID-19
Encephalitis
Herpesviridae
SARS-CoV-2

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https://doi.org/10.1007/s13365-023-01132-4

Cite this

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title = "Central nervous system reactivation of herpesviridae family in patients with COVID-19",

abstract = "The objective of this study is to describe our COVID-19 patients with herpesviridae reactivation in the central nervous system (CNS). Four patients were described including two with acute encephalitis and two with acute encephalomyelitis. Three of four patients had abnormal findings on neuroimaging studies. One of four patients died, one survived with major neurological sequelae, and two others fully recovered. Herpesviridae reactivation in the CNS in patients with COVID-19 is a rare but serious coincidence. The optimal therapeutic management has not been investigated and until more information is available, it is prudent to treat these patients with appropriate antivirals with or without anti-inflammatory agents.",

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AU - Boostani, Reza

AU - Layegh, Parvaneh

AU - Rashid-Nejad, Azra

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Central nervous system reactivation of herpesviridae family in patients with COVID-19

Abstract

Keywords

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