TY - JOUR
T1 - Cerebral necrosis after 25 Gy radiotherapy in childhood followed 28 years later by 54 Gy radiotherapy
AU - Koot, Radboud W.
AU - Stalpers, Lukas J. A.
AU - Aronica, Eleonora
AU - Bosch, D. Andries
PY - 2007
Y1 - 2007
N2 - The development of brain necrosis is life-long risk of repeat radiation therapy, even after a long time interval and a moderate radiation dose. We report on a 34-year-old patient who had prophylactic cranial irradiation with 25 Gy and adjuvant chemotherapy in childhood for leukaemia and in adulthood, 28 years later, therapeutic radiotherapy with 54 Gy for an atypical (WHO grade 11) meningioma. About 2 years later he developed a contrast-enhancing lesion on MRI-scan that was indicative of a tumor according to a thallium-201 ((TI)-T-201) SPECT scan. Histopathology of the operated contrast-enhancing lesion showed extensive radionecrosis. Radiation necrosis is a small but serious risk after repeat radiation therapy, even after a very long-term interval, the delivery of small fractions and an average cumulative total dose. Patients undergoing repeat radiotherapy therefore need to be followed life-long for potential late radiation toxicity. (c) 2007 Elsevier B.V. All rights reserved
AB - The development of brain necrosis is life-long risk of repeat radiation therapy, even after a long time interval and a moderate radiation dose. We report on a 34-year-old patient who had prophylactic cranial irradiation with 25 Gy and adjuvant chemotherapy in childhood for leukaemia and in adulthood, 28 years later, therapeutic radiotherapy with 54 Gy for an atypical (WHO grade 11) meningioma. About 2 years later he developed a contrast-enhancing lesion on MRI-scan that was indicative of a tumor according to a thallium-201 ((TI)-T-201) SPECT scan. Histopathology of the operated contrast-enhancing lesion showed extensive radionecrosis. Radiation necrosis is a small but serious risk after repeat radiation therapy, even after a very long-term interval, the delivery of small fractions and an average cumulative total dose. Patients undergoing repeat radiotherapy therefore need to be followed life-long for potential late radiation toxicity. (c) 2007 Elsevier B.V. All rights reserved
U2 - https://doi.org/10.1016/j.clineuro.2007.04.013
DO - https://doi.org/10.1016/j.clineuro.2007.04.013
M3 - Article
C2 - 17555870
SN - 0303-8467
VL - 109
SP - 607
EP - 612
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 7
ER -