TY - JOUR
T1 - Cerebrospinal Fluid Amyloid-β Subtypes in Confirmed Frontotemporal Lobar Degeneration Cases
T2 - A Pilot Study
AU - Verwey, Nicolaas A.
AU - Teunissen, Charlotte E.
AU - Hoozemans, Jeroen J. M.
AU - Rozemuller, Annemieke J. M.
AU - Scheltens, Philip
AU - Pijnenburg, Yolande A. L.
PY - 2019
Y1 - 2019
N2 - To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.
AB - To investigate amyloid-β (Aβ) in frontotemporal dementia (FTD), cerebrospinal fluid (CSF) Aβ38, Aβ40, and Aβ42 in frontotemporal lobar degeneration (FTLD; N = 18 genetically and/or pathologically confirmed and N = 8 FTD with concomitant amyotrophic lateral sclerosis) were compared with Alzheimer's disease (AD; pathological or Pittsburgh-compound-B Positron-emission-tomography (PIB-PET) positive; N = 25) and controls (N = 24). For all the Aβ subtypes, group difference was seen and post-hoc analysis revealed lower levels in FTLD compared to controls (p≤0.05). Aβ42/40 ratio showed no difference between FTLD and controls; however, a difference was seen between AD versus FTLD (p < 0.01). This is an intriguing finding, suggesting a possible role of Aβ in FTLD pathogenesis.
KW - Alzheimer's disease
KW - amyloid
KW - frontotemporal dementia
KW - frontotemporal lobar degeneration
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071900358&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31356209
U2 - https://doi.org/10.3233/JAD-190344
DO - https://doi.org/10.3233/JAD-190344
M3 - Article
C2 - 31356209
SN - 1387-2877
VL - 71
SP - 15
EP - 20
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -