TY - JOUR
T1 - Changes in the serum concentration and the glycosylation of human α1-acid glycoprotein and α1-protease inhibitor in severely burned persons
T2 - Relation to interleukin-6 levels
AU - Pos, O.
AU - Van der Stelt, M. E.
AU - Wolbink, G. J.
AU - Nijsten, M. W.N.
AU - Van der Tempel, G. L.
AU - Van Dijk, W.
PY - 1990
Y1 - 1990
N2 - The relation between interleukin-6 (IL-6) levels and changes in serum concentrations and glycosylation (concanavalin A affinity) of two human acute-phase glycoproteins, α1-acid glycoprotein (AGP) and α1-protease inhibitor (PI), was studied in sequential serum samples of burn patients. The level of IL-6 was already increased at the first day following injury, and after a dip at day 2 or 3 rapidly reached a second maximal value at day 4 or 5. The serum concentrations of AGP and PI reached their maximal values after day 5 and remained at a high level throughout the total period studied (7 weeks). The concanavalin A reactivities of both acute-phase glycoproteins were found to be elevated only during the first 2-2.5 weeks. Maximal values were observed on day 2 and from day 7 to 16, following closely the rise and fall of the IL-6 serum level. After day 16, the concanavalin A affinity rapidly declined long before a decrease was observed in the serum concentrations of AGP and PI. Our previous in vitro studies have indicated an involvement of IL-6 in the induction of both secretion and increased concanavalin A affinity. This study indicates that IL-6 could play a causal role in the induction of both phenomena in vivo.
AB - The relation between interleukin-6 (IL-6) levels and changes in serum concentrations and glycosylation (concanavalin A affinity) of two human acute-phase glycoproteins, α1-acid glycoprotein (AGP) and α1-protease inhibitor (PI), was studied in sequential serum samples of burn patients. The level of IL-6 was already increased at the first day following injury, and after a dip at day 2 or 3 rapidly reached a second maximal value at day 4 or 5. The serum concentrations of AGP and PI reached their maximal values after day 5 and remained at a high level throughout the total period studied (7 weeks). The concanavalin A reactivities of both acute-phase glycoproteins were found to be elevated only during the first 2-2.5 weeks. Maximal values were observed on day 2 and from day 7 to 16, following closely the rise and fall of the IL-6 serum level. After day 16, the concanavalin A affinity rapidly declined long before a decrease was observed in the serum concentrations of AGP and PI. Our previous in vitro studies have indicated an involvement of IL-6 in the induction of both secretion and increased concanavalin A affinity. This study indicates that IL-6 could play a causal role in the induction of both phenomena in vivo.
KW - Glycosylation
KW - Inflammation
KW - Interleukin-6
KW - α1-acid glycoprotein
KW - α1-protease inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0025201215&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/j.1365-2249.1990.tb05493.x
DO - https://doi.org/10.1111/j.1365-2249.1990.tb05493.x
M3 - Article
C2 - 2265495
SN - 0009-9104
VL - 82
SP - 579
EP - 582
JO - Clinical and experimental immunology
JF - Clinical and experimental immunology
IS - 3
ER -