TY - JOUR
T1 - Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children
AU - Lebbink, Chantal A.
AU - Bresters, Dorine
AU - Tersteeg, Joni P. B.
AU - van den Bos, Cor
AU - Dierselhuis, Miranda P.
AU - Lentjes, Eef G. W. M.
AU - Verrijn Stuart, Annemarie A.
AU - Fiocco, Marta
AU - Tissing, Wim J. E.
AU - van Santen, Hanneke M.
N1 - Funding Information: Supported by Stichting Kinderen Kankervrij (KiKa). Conflicts of interest: None declared. Publisher Copyright: © The Author(s) 2023.
PY - 2023/6/7
Y1 - 2023/6/7
N2 - Background: Thyroid dysfunction (hypo- and hyperthyroidism) has been reported as a late effect after hematopoietic stem cell transplantation (HSCT) in children. Short-term effects of HSCT on thyroid function parameters are, however, unclear. Methods: We prospectively evaluated thyroid function parameters before and 3 months after HSCT in all children (<21 years) who underwent HSCT during a 2-year period in the Princess Máxima Center, the Netherlands. Results: Among 72 children, none had thyroidal hypothyroidism or hyperthyroidism 3 months after HSCT. Changes in thyroid function parameters (either aberrant thyroid-stimulating hormone [TSH] or free thyroxine [FT4] concentrations) were found in 16% before and in 10% 3 months after HSCT. Reverse triiodothyronine (rT3) was found elevated in 9.3% before and in 37% 3 months after HSCT, which could be related to poor physical condition. An individual decline in FT4 concentration of ≥20% was found in 10.5% (6/57) 3 months after HSCT. Conclusion: In conclusion, thyroidal hypo- and hyperthyroidism are very rare 3 months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found 3 months after HSCT might reflect euthyroid sick syndrome.
AB - Background: Thyroid dysfunction (hypo- and hyperthyroidism) has been reported as a late effect after hematopoietic stem cell transplantation (HSCT) in children. Short-term effects of HSCT on thyroid function parameters are, however, unclear. Methods: We prospectively evaluated thyroid function parameters before and 3 months after HSCT in all children (<21 years) who underwent HSCT during a 2-year period in the Princess Máxima Center, the Netherlands. Results: Among 72 children, none had thyroidal hypothyroidism or hyperthyroidism 3 months after HSCT. Changes in thyroid function parameters (either aberrant thyroid-stimulating hormone [TSH] or free thyroxine [FT4] concentrations) were found in 16% before and in 10% 3 months after HSCT. Reverse triiodothyronine (rT3) was found elevated in 9.3% before and in 37% 3 months after HSCT, which could be related to poor physical condition. An individual decline in FT4 concentration of ≥20% was found in 10.5% (6/57) 3 months after HSCT. Conclusion: In conclusion, thyroidal hypo- and hyperthyroidism are very rare 3 months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found 3 months after HSCT might reflect euthyroid sick syndrome.
KW - hematopoietic stem cell transplantation
KW - pediatrics
KW - thyroid dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85163920949&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ejendo/lvad058
DO - https://doi.org/10.1093/ejendo/lvad058
M3 - Article
C2 - 37232272
SN - 0804-4643
VL - 188
SP - 503
EP - 509
JO - European journal of endocrinology
JF - European journal of endocrinology
IS - 6
ER -