TY - JOUR
T1 - Characteristics of heart failure in the Amsterdam metropolitan area (AMSTERDAM-HF)
T2 - Data from a dynamic general practice cohort (2011−2021)
AU - de Clercq, Lukas
AU - Er, Amine
AU - Handoko, M. Louis
AU - van Weert, Henk C. P. M.
AU - Schut, Martijn C.
AU - Moll van Charante, Eric P.
AU - Himmelreich, Jelle C. L.
AU - Harskamp, Ralf E.
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023/10/15
Y1 - 2023/10/15
N2 - Background: Heart failure (HF) is a common cardiac syndrome with a high disease burden and poor prognosis in our aging populations. Understanding the characteristics of patients with newly diagnosed HF is essential for improving care and outcomes. The AMSTERDAM-HF study is aimed to examine the population characteristics of patients with incident HF. Methods: We performed a retrospective dynamic cohort study in the Amsterdam general practice network consisting of 904,557 individuals. Incidence HF rates, geographical demographics, patient characteristics, risk factors, symptoms prior to HF diagnosis, and prognosis were reported. Results: The study identified 10,067 new cases of HF over 6,816,099 person-years. The median age of patients was 77 years (25th–75th percentile: 66–85), and 48% were male. The incidence rate of HF was 213.44 per 100,000 patient-years, and was higher in male versus female patients (incidence rate ratio: 1.08, 95%-CI:1.04–1.13). Hypertension (men 46.3% and women 55.8%), coronary artery disease (men 36% and women 25%) and diabetes mellitus (men 30.5% and women 26.8%) were the most common risk factors. Dyspnoea and oedema were key reported symptoms prior to HF diagnosis. Survival rates at 10-year follow-up were poor, particularly in men (36.4%) compared to women (39.7%). Incidence rates, comorbidity burden and prognosis were worse in city districts with high ethnic diversity and low socio-economic position. Conclusion: Our study provides insights into incident HF in a contemporary Western European, multi-ethnic, urban population. It highlights notable sex, age, and geographical differences in incidence rates, risk factors, symptoms and prognosis.
AB - Background: Heart failure (HF) is a common cardiac syndrome with a high disease burden and poor prognosis in our aging populations. Understanding the characteristics of patients with newly diagnosed HF is essential for improving care and outcomes. The AMSTERDAM-HF study is aimed to examine the population characteristics of patients with incident HF. Methods: We performed a retrospective dynamic cohort study in the Amsterdam general practice network consisting of 904,557 individuals. Incidence HF rates, geographical demographics, patient characteristics, risk factors, symptoms prior to HF diagnosis, and prognosis were reported. Results: The study identified 10,067 new cases of HF over 6,816,099 person-years. The median age of patients was 77 years (25th–75th percentile: 66–85), and 48% were male. The incidence rate of HF was 213.44 per 100,000 patient-years, and was higher in male versus female patients (incidence rate ratio: 1.08, 95%-CI:1.04–1.13). Hypertension (men 46.3% and women 55.8%), coronary artery disease (men 36% and women 25%) and diabetes mellitus (men 30.5% and women 26.8%) were the most common risk factors. Dyspnoea and oedema were key reported symptoms prior to HF diagnosis. Survival rates at 10-year follow-up were poor, particularly in men (36.4%) compared to women (39.7%). Incidence rates, comorbidity burden and prognosis were worse in city districts with high ethnic diversity and low socio-economic position. Conclusion: Our study provides insights into incident HF in a contemporary Western European, multi-ethnic, urban population. It highlights notable sex, age, and geographical differences in incidence rates, risk factors, symptoms and prognosis.
KW - Amsterdam
KW - Heart failure
KW - Incidence
KW - Primary care
KW - Prognosis
KW - Urban population
UR - http://www.scopus.com/inward/record.url?scp=85168993871&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijcard.2023.131217
DO - https://doi.org/10.1016/j.ijcard.2023.131217
M3 - Article
C2 - 37499948
SN - 0167-5273
VL - 389
JO - International journal of cardiology
JF - International journal of cardiology
M1 - 131217
ER -