Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Susana Brun; Wissam Beaino; Laurent Kremer; Omar Taleb; Ayikoe Guy Mensah-Nyagan; Chanh D. Lam; Judith M. Greer; JérÔme de Seze; Elisabeth Trifilieff

doi:https://doi.org/10.1016/j.jneuroim.2014.11.022

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Susana Brun, Wissam Beaino, Laurent Kremer, Omar Taleb, Ayikoe Guy Mensah-Nyagan, Chanh D. Lam, Judith M. Greer, JérÔme de Seze, Elisabeth Trifilieff

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17⁺ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	278
DOIs	https://doi.org/10.1016/j.jneuroim.2014.11.022
Publication status	Published - 1 Jan 2015
Externally published	Yes

Keywords

Animal model
CIDP
Chronic EAN
Electrophysiology
Immunology
Sciatic nerve immunohistochemistry
Thiopalmitoylated P0 peptide

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https://doi.org/10.1016/j.jneuroim.2014.11.022

Cite this

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title = "Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies",

abstract = "Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.",

keywords = "Animal model, CIDP, Chronic EAN, Electrophysiology, Immunology, Sciatic nerve immunohistochemistry, Thiopalmitoylated P0 peptide",

author = "Susana Brun and Wissam Beaino and Laurent Kremer and Omar Taleb and Mensah-Nyagan, {Ayikoe Guy} and Lam, {Chanh D.} and Greer, {Judith M.} and {de Seze}, J{\'e}r{\^O}me and Elisabeth Trifilieff",

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AU - Brun, Susana

AU - Beaino, Wissam

AU - Kremer, Laurent

AU - Taleb, Omar

AU - Mensah-Nyagan, Ayikoe Guy

AU - Lam, Chanh D.

AU - Greer, Judith M.

AU - de Seze, JérÔme

AU - Trifilieff, Elisabeth

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.

AB - Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.

KW - Animal model

KW - CIDP

KW - Chronic EAN

KW - Electrophysiology

KW - Immunology

KW - Sciatic nerve immunohistochemistry

KW - Thiopalmitoylated P0 peptide

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SP - 1

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Abstract

Keywords

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