Characterization of animal models for primary sclerosing cholangitis (PSC)

Peter Fickert; Marion J. Pollheimer; Ulrich Beuers; Carolin Lackner; Gideon Hirschfield; Chantal Housset; Verena Keitel; Christoph Schramm; Hanns-Ulrich Marschall; Tom H. Karlsen; Espen Melum; Arthur Kaser; Bertus Eksteen; Mario Strazzabosco; Michael Manns; Michael Trauner

doi:https://doi.org/10.1016/j.jhep.2014.02.006

Characterization of animal models for primary sclerosing cholangitis (PSC)

Peter Fickert, Marion J. Pollheimer, Ulrich Beuers, Carolin Lackner, Gideon Hirschfield, Chantal Housset, Verena Keitel, Christoph Schramm, Hanns-Ulrich Marschall, Tom H. Karlsen, Espen Melum, Arthur Kaser, Bertus Eksteen, Mario Strazzabosco, Michael Manns, Michael Trauner

Research output: Contribution to journal › Review article › Academic › peer-review

123 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC

Original language	English
Pages (from-to)	1290-1303
Journal	Journal of Hepatology
Volume	60
Issue number	6
DOIs	https://doi.org/10.1016/j.jhep.2014.02.006
Publication status	Published - 2014

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https://doi.org/10.1016/j.jhep.2014.02.006

Cite this

Fickert, P., Pollheimer, M. J., Beuers, U., Lackner, C., Hirschfield, G., Housset, C., Keitel, V., Schramm, C., Marschall, H.-U., Karlsen, T. H., Melum, E., Kaser, A., Eksteen, B., Strazzabosco, M., Manns, M., & Trauner, M. (2014). Characterization of animal models for primary sclerosing cholangitis (PSC). Journal of Hepatology, 60(6), 1290-1303. https://doi.org/10.1016/j.jhep.2014.02.006

@article{390333ddd140488da5c516b967286cf6,

title = "Characterization of animal models for primary sclerosing cholangitis (PSC)",

abstract = "Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC",

author = "Peter Fickert and Pollheimer, {Marion J.} and Ulrich Beuers and Carolin Lackner and Gideon Hirschfield and Chantal Housset and Verena Keitel and Christoph Schramm and Hanns-Ulrich Marschall and Karlsen, {Tom H.} and Espen Melum and Arthur Kaser and Bertus Eksteen and Mario Strazzabosco and Michael Manns and Michael Trauner",

year = "2014",

doi = "https://doi.org/10.1016/j.jhep.2014.02.006",

language = "English",

volume = "60",

pages = "1290--1303",

journal = "Journal of Hepatology",

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publisher = "Elsevier",

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Fickert, P, Pollheimer, MJ, Beuers, U, Lackner, C, Hirschfield, G, Housset, C, Keitel, V, Schramm, C, Marschall, H-U, Karlsen, TH, Melum, E, Kaser, A, Eksteen, B, Strazzabosco, M, Manns, M & Trauner, M 2014, 'Characterization of animal models for primary sclerosing cholangitis (PSC)', Journal of Hepatology, vol. 60, no. 6, pp. 1290-1303. https://doi.org/10.1016/j.jhep.2014.02.006

TY - JOUR

T1 - Characterization of animal models for primary sclerosing cholangitis (PSC)

AU - Fickert, Peter

AU - Pollheimer, Marion J.

AU - Beuers, Ulrich

AU - Lackner, Carolin

AU - Hirschfield, Gideon

AU - Housset, Chantal

AU - Keitel, Verena

AU - Schramm, Christoph

AU - Marschall, Hanns-Ulrich

AU - Karlsen, Tom H.

AU - Melum, Espen

AU - Kaser, Arthur

AU - Eksteen, Bertus

AU - Strazzabosco, Mario

AU - Manns, Michael

AU - Trauner, Michael

PY - 2014

Y1 - 2014

N2 - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC

AB - Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC

U2 - https://doi.org/10.1016/j.jhep.2014.02.006

DO - https://doi.org/10.1016/j.jhep.2014.02.006

M3 - Review article

C2 - 24560657

SN - 0168-8278

VL - 60

SP - 1290

EP - 1303

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 6

ER -