TY - JOUR
T1 - Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2
AU - Ribeiro, Luisa
AU - Bandello, Francesco
AU - Tejerina, Amparo Navea
AU - Vujosevic, Stela
AU - Varano, Monica
AU - Egan, Catherine
AU - Sivaprasad, Sobha
AU - Menon, Geeta
AU - Massin, Pascale
AU - Verbraak, Frank D.
AU - Lund-Andersen, Henrik
AU - Martinez, Jose P.
AU - Jürgens, Ignasi
AU - Smets, Erica
AU - Coriat, Caroline
AU - Wiedemann, Peter
AU - Ágoas, Victor
AU - Querques, Giuseppe
AU - Holz, Frank G.
AU - Nunes, Sandrina
AU - Neves, Catarina
AU - Cunha-Vaz, José
AU - AUTHOR GROUP
AU - Ribeiro, Luísa
AU - Figueira, João
AU - Pires, Isabel
AU - Leal, Sérgio
AU - Simão, Silvia
AU - Santos, Ana Rita
AU - Simões, Isabel
AU - Souied, Eric H.
AU - Boston, Hayley
AU - Degli Esposti, Simona
AU - Rocco, Vincent
AU - Mathysen, Danny G. P.
AU - Erginay, Ali
AU - Fleckenstein, Monika
AU - Cacciamani, Andrea
AU - Parravano, Mariacristina
AU - Cosimi, Pamela
AU - Mourits, M.
AU - Schlingemann, R. O.
AU - Wezel, M.
AU - Jansen-Kok, C.
AU - Althoff, A.
AU - de Vries, D.
AU - Stam, M.
AU - Jochmann, Claudia
AU - Koch, Christian
AU - Vollhardt, Daniela
AU - Tilgner, Christina
PY - 2015
Y1 - 2015
N2 - PURPOSE. To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS. Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in a 12-month prospective observational study to identify retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using spectral-domain optical coherence tomography (SD-OCT) were assessed by a central reading center at all visits and ETDRS severity level in the first and last visits. RESULTS. Three hundred thirty-one eyes/patients completed the study. Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher MA turnover values were registered in eyes that showed progression in ETDRS severity level (P <0.03). There were also significant correlations between increased microaneurysm activity and increases in retinal thickness. Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Progression of retinal thickening was registered in eyes that had either subclinical or clinical macular edema at baseline. CONCLUSIONS. Changes in MA activity measured with RetmarkerDR and in central retinal thickness in eyes with mild nonproliferative diabetic retinopathy and diabetes type 2 are able to identify eyes at risk of progression. These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to visionthreatening complications
AB - PURPOSE. To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. METHODS. Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in a 12-month prospective observational study to identify retinopathy progression. Four visits were scheduled at 0, 3, 6, and 12 months. Microaneurysm (MA) activity using the RetmarkerDR and retinal thickness using spectral-domain optical coherence tomography (SD-OCT) were assessed by a central reading center at all visits and ETDRS severity level in the first and last visits. RESULTS. Three hundred thirty-one eyes/patients completed the study. Microaneurysm formation rate greater than or equal to 2 was present in 68.1% of the eyes and MA turnover greater than or equal to 6 in 54.0% at month 6. Higher MA turnover values were registered in eyes that showed progression in ETDRS severity level (P <0.03). There were also significant correlations between increased microaneurysm activity and increases in retinal thickness. Spectral-domain OCT identified clinical macular edema in 24 eyes/patients (6.7%) and subclinical macular edema in 104 eyes/patients (28.9%) at baseline. Progression of retinal thickening was registered in eyes that had either subclinical or clinical macular edema at baseline. CONCLUSIONS. Changes in MA activity measured with RetmarkerDR and in central retinal thickness in eyes with mild nonproliferative diabetic retinopathy and diabetes type 2 are able to identify eyes at risk of progression. These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to visionthreatening complications
U2 - https://doi.org/10.1167/iovs.15-16708
DO - https://doi.org/10.1167/iovs.15-16708
M3 - Article
C2 - 26322834
SN - 0146-0404
VL - 56
SP - 5698
EP - 5705
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 9
ER -