Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes

E. van de Vosse; S. M. Walpole; A. Nicolaou; P. van der Bent; A. Cahn; M. Vaudin; M. T. Ross; J. Durham; R. Pavitt; J. Wilkinson; D. Grafham; A. A. Bergen; G. J. van Ommen; J. R. Yates; J. T. den Dunnen; D. Trump

doi:https://doi.org/10.1006/geno.1998.5224

Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes

E. van de Vosse, S. M. Walpole, A. Nicolaou, P. van der Bent, A. Cahn, M. Vaudin, M. T. Ross, J. Durham, R. Pavitt, J. Wilkinson, D. Grafham, A. A. Bergen, G. J. van Ommen, J. R. Yates, J. T. den Dunnen, D. Trump

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Abstract

Using exon trapping, we have identified a new human gene in Xp22 encoding a 3-kb mRNA. Expression of this RNA is detectable in a range of tissues but is most pronounced in skeletal muscle and heart. The gene, designated "sex comb on midleg-like-1" (SCML1), maps 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, and is transcribed from telomere to centromere. SCML1 spans 18 kb of genomic DNA, consists of six exons, and has a 624-bp open reading frame. The predicted 27-kDa SCML1 protein contains two domains that each have a high homology to two Drosophila transcriptional repressors of the polycomb group (PcG) genes and their homologues in mouse and human. PcG genes are known to be involved in the regulation of homeotic genes, and the mammalian homologues of the PcG genes repress the expression of Hox genes. SCML1 appears to be a new human member of this gene group and may play an important role in the control of embryonal development

Original language	English
Pages (from-to)	96-102
Journal	Genomics
Volume	49
Issue number	1
DOIs	https://doi.org/10.1006/geno.1998.5224
Publication status	Published - 1998

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https://doi.org/10.1006/geno.1998.5224

Cite this

van de Vosse, E., Walpole, S. M., Nicolaou, A., van der Bent, P., Cahn, A., Vaudin, M., Ross, M. T., Durham, J., Pavitt, R., Wilkinson, J., Grafham, D., Bergen, A. A., van Ommen, G. J., Yates, J. R., den Dunnen, J. T., & Trump, D. (1998). Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. Genomics, 49(1), 96-102. https://doi.org/10.1006/geno.1998.5224

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title = "Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes",

abstract = "Using exon trapping, we have identified a new human gene in Xp22 encoding a 3-kb mRNA. Expression of this RNA is detectable in a range of tissues but is most pronounced in skeletal muscle and heart. The gene, designated {"}sex comb on midleg-like-1{"} (SCML1), maps 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, and is transcribed from telomere to centromere. SCML1 spans 18 kb of genomic DNA, consists of six exons, and has a 624-bp open reading frame. The predicted 27-kDa SCML1 protein contains two domains that each have a high homology to two Drosophila transcriptional repressors of the polycomb group (PcG) genes and their homologues in mouse and human. PcG genes are known to be involved in the regulation of homeotic genes, and the mammalian homologues of the PcG genes repress the expression of Hox genes. SCML1 appears to be a new human member of this gene group and may play an important role in the control of embryonal development",

author = "{van de Vosse}, E. and Walpole, {S. M.} and A. Nicolaou and {van der Bent}, P. and A. Cahn and M. Vaudin and Ross, {M. T.} and J. Durham and R. Pavitt and J. Wilkinson and D. Grafham and Bergen, {A. A.} and {van Ommen}, {G. J.} and Yates, {J. R.} and {den Dunnen}, {J. T.} and D. Trump",

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van de Vosse, E, Walpole, SM, Nicolaou, A, van der Bent, P, Cahn, A, Vaudin, M, Ross, MT, Durham, J, Pavitt, R, Wilkinson, J, Grafham, D, Bergen, AA, van Ommen, GJ, Yates, JR, den Dunnen, JT & Trump, D 1998, 'Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes', Genomics, vol. 49, no. 1, pp. 96-102. https://doi.org/10.1006/geno.1998.5224

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AU - van de Vosse, E.

AU - Walpole, S. M.

AU - Nicolaou, A.

AU - van der Bent, P.

AU - Cahn, A.

AU - Vaudin, M.

AU - Ross, M. T.

AU - Durham, J.

AU - Pavitt, R.

AU - Wilkinson, J.

AU - Grafham, D.

AU - Bergen, A. A.

AU - van Ommen, G. J.

AU - Yates, J. R.

AU - den Dunnen, J. T.

AU - Trump, D.

PY - 1998

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N2 - Using exon trapping, we have identified a new human gene in Xp22 encoding a 3-kb mRNA. Expression of this RNA is detectable in a range of tissues but is most pronounced in skeletal muscle and heart. The gene, designated "sex comb on midleg-like-1" (SCML1), maps 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, and is transcribed from telomere to centromere. SCML1 spans 18 kb of genomic DNA, consists of six exons, and has a 624-bp open reading frame. The predicted 27-kDa SCML1 protein contains two domains that each have a high homology to two Drosophila transcriptional repressors of the polycomb group (PcG) genes and their homologues in mouse and human. PcG genes are known to be involved in the regulation of homeotic genes, and the mammalian homologues of the PcG genes repress the expression of Hox genes. SCML1 appears to be a new human member of this gene group and may play an important role in the control of embryonal development

AB - Using exon trapping, we have identified a new human gene in Xp22 encoding a 3-kb mRNA. Expression of this RNA is detectable in a range of tissues but is most pronounced in skeletal muscle and heart. The gene, designated "sex comb on midleg-like-1" (SCML1), maps 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, and is transcribed from telomere to centromere. SCML1 spans 18 kb of genomic DNA, consists of six exons, and has a 624-bp open reading frame. The predicted 27-kDa SCML1 protein contains two domains that each have a high homology to two Drosophila transcriptional repressors of the polycomb group (PcG) genes and their homologues in mouse and human. PcG genes are known to be involved in the regulation of homeotic genes, and the mammalian homologues of the PcG genes repress the expression of Hox genes. SCML1 appears to be a new human member of this gene group and may play an important role in the control of embryonal development

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DO - https://doi.org/10.1006/geno.1998.5224

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