TY - JOUR
T1 - Characterizing sleep disorders of adults with tuberous sclerosis complex
T2 - a questionnaire-based study and review
AU - van Eeghen, Agnies M
AU - Numis, Adam I
AU - Staley, Brigid A
AU - Therrien, Samuel E
AU - Thibert, Ronald L
AU - Thiele, Elizabeth A
N1 - Copyright © 2010 Elsevier Inc. All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - An adult cohort with tuberous sclerosis complex was investigated for the prevalence of sleep disturbances and the relationship with seizure variables, medication, and psychological functioning. Information on 35 adults was gathered using four questionnaires: Epworth Sleepiness Scale (ESS), Sleep and Epilepsy Questionnaire (SEQ), Sleep Diagnosis List (SDL), and Adult Self-Report Scale (ASR). In addition, clinical, genetic and electrophysiological data were collected. Of 35 respondents, 25 had a history of epilepsy. A subjective sleep disorder was found in 31% of the cohort. Insomnia scores showed a significant positive correlation with obstructive sleep apnea syndrome and restless legs syndrome scores. Significant correlations were found between daytime sleepiness and scores on depression, antisocial behavior, and use of mental health medication. A subgroup using antiepileptic medication showed high correlations between daytime sleepiness, attention deficits, and anxiety scores.
AB - An adult cohort with tuberous sclerosis complex was investigated for the prevalence of sleep disturbances and the relationship with seizure variables, medication, and psychological functioning. Information on 35 adults was gathered using four questionnaires: Epworth Sleepiness Scale (ESS), Sleep and Epilepsy Questionnaire (SEQ), Sleep Diagnosis List (SDL), and Adult Self-Report Scale (ASR). In addition, clinical, genetic and electrophysiological data were collected. Of 35 respondents, 25 had a history of epilepsy. A subjective sleep disorder was found in 31% of the cohort. Insomnia scores showed a significant positive correlation with obstructive sleep apnea syndrome and restless legs syndrome scores. Significant correlations were found between daytime sleepiness and scores on depression, antisocial behavior, and use of mental health medication. A subgroup using antiepileptic medication showed high correlations between daytime sleepiness, attention deficits, and anxiety scores.
KW - Adult
KW - DNA Mutational Analysis
KW - Electroencephalography
KW - Female
KW - Humans
KW - Male
KW - Sleep Wake Disorders/complications
KW - Surveys and Questionnaires
KW - Tuberous Sclerosis/complications
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78651239029&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/21130696
U2 - https://doi.org/10.1016/j.yebeh.2010.10.023
DO - https://doi.org/10.1016/j.yebeh.2010.10.023
M3 - Article
C2 - 21130696
SN - 1525-5050
VL - 20
SP - 68
EP - 74
JO - Epilepsy & Behavior
JF - Epilepsy & Behavior
IS - 1
ER -