Charting the dynamic methylome across the human lifespan

RC Slieker

Charting the dynamic methylome across the human lifespan

Research output: PhD Thesis › Phd-Thesis - Research and graduation external

Abstract

In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first two empirical chapters of this thesis describe the establishment and the maintenance of the epigenome during fetal development and in later life in multiple tissues. In the subsequent two chapters we investigated the loss of control over the methylome in blood and other tissues.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Leiden University
Supervisors/Advisors	Slagboom, Pieternella E., Supervisor, External person Heijmans, Bastiaan T., Co-supervisor, External person
Award date	9 Feb 2017
Print ISBNs	9789462335103
Publication status	Published - 2017

Access to Document

http://hdl.handle.net/1887/45888

Cite this

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AB - In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first two empirical chapters of this thesis describe the establishment and the maintenance of the epigenome during fetal development and in later life in multiple tissues. In the subsequent two chapters we investigated the loss of control over the methylome in blood and other tissues.

M3 - Phd-Thesis - Research and graduation external

SN - 9789462335103

ER -