Charting the dynamic methylome across the human lifespan

Research output: PhD ThesisPhd-Thesis - Research and graduation external


In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first two empirical chapters of this thesis describe the establishment and the maintenance of the epigenome during fetal development and in later life in multiple tissues. In the subsequent two chapters we investigated the loss of control over the methylome in blood and other tissues.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Leiden University
  • Slagboom, Pieternella E., Supervisor, External person
  • Heijmans, Bastiaan T., Co-supervisor, External person
Award date9 Feb 2017
Print ISBNs9789462335103
Publication statusPublished - 2017

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