TY - JOUR
T1 - Chemoradiotherapy in tumours of the oesophagus and gastro-oesophageal junction
AU - Hulshof, M. C. C. M.
AU - van Laarhoven, H. W. M.
PY - 2016
Y1 - 2016
N2 - Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10-15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT has changed the treatment intent from palliative to curative. Definitive CRT is a good alternative for radical surgery in responding patients with squamous cell carcinoma and those running a high risk of surgical morbidity and mortality. For patients with an out-of-field solitary locoregional recurrence after primary curative treatment, definitive CRT can lead to long term survival
AB - Oesophageal cancer remains a malignancy with a poor prognosis. However, in the recent 10-15 years relevant progress has been made by the introduction of chemoradiotherapy (CRT) for tumours of the oesophagus or gastro-oesophageal junction. The addition of neo-adjuvant CRT to surgery has significantly improved survival and locoregional control, for both adenocarcinoma and squamous cell carcinoma. For irresectable or medically inoperable patients, definitive CRT has changed the treatment intent from palliative to curative. Definitive CRT is a good alternative for radical surgery in responding patients with squamous cell carcinoma and those running a high risk of surgical morbidity and mortality. For patients with an out-of-field solitary locoregional recurrence after primary curative treatment, definitive CRT can lead to long term survival
U2 - https://doi.org/10.1016/j.bpg.2016.06.002
DO - https://doi.org/10.1016/j.bpg.2016.06.002
M3 - Article
C2 - 27644904
SN - 1521-6918
VL - 30
SP - 551
EP - 563
JO - Best practice & research. Clinical gastroenterology
JF - Best practice & research. Clinical gastroenterology
IS - 4
ER -