TY - JOUR
T1 - Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent
AU - Mekenkamp, Leonie J. M.
AU - Haan, Josien C.
AU - Israeli, Daniëlle
AU - van Essen, Hendrik F. B.
AU - Dijkstra, Jeroen R.
AU - van Cleef, Patricia
AU - Punt, Cornelis J. A.
AU - Meijer, Gerrit A.
AU - Nagtegaal, Iris D.
AU - Ylstra, Bauke
PY - 2014
Y1 - 2014
N2 - The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent
AB - The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent
U2 - https://doi.org/10.1371/journal.pone.0086833
DO - https://doi.org/10.1371/journal.pone.0086833
M3 - Article
C2 - 24505270
SN - 1932-6203
VL - 9
SP - e86833
JO - PLOS ONE
JF - PLOS ONE
IS - 2
M1 - e86833
ER -