TY - JOUR
T1 - Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis
AU - Wiewel, Maryse A.
AU - de Stoppelaar, Sacha F.
AU - van Vught, Lonneke A.
AU - Frencken, Jos F.
AU - Hoogendijk, Arie J.
AU - Klein Klouwenberg, Peter M. C.
AU - Horn, Janneke
AU - Bonten, Marc J.
AU - Zwinderman, Aeilko H.
AU - Cremer, Olaf L.
AU - Schultz, Marcus J.
AU - van der Poll, Tom
AU - AUTHOR GROUP
AU - de Beer, Friso M.
AU - Bos, Lieuwe D. J.
AU - Glas, Gerie J.
AU - van Hooijdonk, Roosmarijn T. M.
AU - Huson, Mischa A.
AU - Ong, David S. Y.
AU - Schouten, Laura R. A.
AU - Scicluna, Brendon P.
AU - Straat, Marleen
AU - Witteveen, Esther
AU - Wieske, Luuk
PY - 2016
Y1 - 2016
N2 - Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of sepsis, and the host response. We performed a prospective observational study in 972 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013. Of them, 267 patients (27.5%) were on antiplatelet therapy (95.9% acetylsalicylic acid) before admission. To account for differential likelihoods of receiving antiplatelet therapy, a propensity score was constructed, including variables associated with use of antiplatelet therapy. Cox proportional hazards regression was used to estimate the association of antiplatelet therapy with mortality. Antiplatelet therapy was not associated with sepsis severity at presentation, the primary source of infection, causative pathogens, the development of organ failure or shock during ICU stay, or mortality up to 90 days after admission, in either unmatched or propensity-matched analyses. Antiplatelet therapy did not modify the values of 19 biomarkers providing insight into hallmark host responses to sepsis, including activation of the coagulation system, the vascular endothelium, the cytokine network, and renal function, during the first 4 days after ICU admission. Pre-existing antiplatelet therapy is not associated with alterations in the presentation or outcome of sepsis, or the host response
AB - Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of sepsis, and the host response. We performed a prospective observational study in 972 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013. Of them, 267 patients (27.5%) were on antiplatelet therapy (95.9% acetylsalicylic acid) before admission. To account for differential likelihoods of receiving antiplatelet therapy, a propensity score was constructed, including variables associated with use of antiplatelet therapy. Cox proportional hazards regression was used to estimate the association of antiplatelet therapy with mortality. Antiplatelet therapy was not associated with sepsis severity at presentation, the primary source of infection, causative pathogens, the development of organ failure or shock during ICU stay, or mortality up to 90 days after admission, in either unmatched or propensity-matched analyses. Antiplatelet therapy did not modify the values of 19 biomarkers providing insight into hallmark host responses to sepsis, including activation of the coagulation system, the vascular endothelium, the cytokine network, and renal function, during the first 4 days after ICU admission. Pre-existing antiplatelet therapy is not associated with alterations in the presentation or outcome of sepsis, or the host response
U2 - https://doi.org/10.1007/s00134-015-4171-9
DO - https://doi.org/10.1007/s00134-015-4171-9
M3 - Article
C2 - 26768440
SN - 0342-4642
VL - 42
SP - 352
EP - 360
JO - Intensive care medicine
JF - Intensive care medicine
IS - 3
ER -