TY - JOUR
T1 - Chronic hepatitis E resolved by reduced immunosuppression in pediatric kidney transplant patients
AU - Bouts, Antonia H. M.
AU - Schriemer, Pytrik J.
AU - Zaaijer, Hans L.
PY - 2015
Y1 - 2015
N2 - At present, transient asymptomatic hepatitis E virus (HEV) infection is common among healthy adults in Western Europe, as reported by blood transfusion services. In immune-suppressed patients HEV infection is often without clinical symptoms, but without therapeutic intervention it may become chronic and lead to cirrhosis. This report describes the course of chronic HEV infection after kidney transplantation in 2 children, who cleared the virus after reduction in immunosuppressive therapy. If aminotransferase levels continue to be moderately elevated after transplantation, HEV infection should be excluded
AB - At present, transient asymptomatic hepatitis E virus (HEV) infection is common among healthy adults in Western Europe, as reported by blood transfusion services. In immune-suppressed patients HEV infection is often without clinical symptoms, but without therapeutic intervention it may become chronic and lead to cirrhosis. This report describes the course of chronic HEV infection after kidney transplantation in 2 children, who cleared the virus after reduction in immunosuppressive therapy. If aminotransferase levels continue to be moderately elevated after transplantation, HEV infection should be excluded
U2 - https://doi.org/10.1542/peds.2014-3790
DO - https://doi.org/10.1542/peds.2014-3790
M3 - Article
C2 - 25755234
SN - 0031-4005
VL - 135
SP - e1075-e1078
JO - Pediatrics
JF - Pediatrics
IS - 4
ER -