Circadian disruption and SCN control of energy metabolism

Andries Kalsbeek; Frank A. Scheer; Stephanie Perreau-Lenz; Susanne E. la Fleur; Chun-Xia Yi; Eric Fliers; Ruud M. Buijs

doi:https://doi.org/10.1016/j.febslet.2011.03.021

Circadian disruption and SCN control of energy metabolism

Andries Kalsbeek, Frank A. Scheer, Stephanie Perreau-Lenz, Susanne E. la Fleur, Chun-Xia Yi, Eric Fliers, Ruud M. Buijs

Research output: Contribution to journal › Review article › Academic › peer-review

97 Citations (Scopus)

Abstract

In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing "diabetogenic" pressure of today's 24/7 society. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

Original language	English
Pages (from-to)	1412-1426
Journal	FEBS letters
Volume	585
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2011.03.021
Publication status	Published - 2011

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https://doi.org/10.1016/j.febslet.2011.03.021

Cite this

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title = "Circadian disruption and SCN control of energy metabolism",

abstract = "In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing {"}diabetogenic{"} pressure of today's 24/7 society. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved",

author = "Andries Kalsbeek and Scheer, {Frank A.} and Stephanie Perreau-Lenz and {la Fleur}, {Susanne E.} and Chun-Xia Yi and Eric Fliers and Buijs, {Ruud M.}",

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TY - JOUR

T1 - Circadian disruption and SCN control of energy metabolism

AU - Kalsbeek, Andries

AU - Scheer, Frank A.

AU - Perreau-Lenz, Stephanie

AU - la Fleur, Susanne E.

AU - Yi, Chun-Xia

AU - Fliers, Eric

AU - Buijs, Ruud M.

PY - 2011

Y1 - 2011

N2 - In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing "diabetogenic" pressure of today's 24/7 society. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

AB - In this review we first present the anatomical pathways used by the suprachiasmatic nuclei to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing "diabetogenic" pressure of today's 24/7 society. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved

U2 - https://doi.org/10.1016/j.febslet.2011.03.021

DO - https://doi.org/10.1016/j.febslet.2011.03.021

M3 - Review article

C2 - 21414317

SN - 0014-5793

VL - 585

SP - 1412

EP - 1426

JO - FEBS letters

JF - FEBS letters

IS - 10

ER -