TY - JOUR
T1 - Circumstances of death in adult congenital heart disease
AU - Zomer, A. Carla
AU - Vaartjes, Ilonca
AU - Uiterwaal, Cuno S. P. M.
AU - van der Velde, Enno T.
AU - van den Merkhof, Lambert F. M.
AU - Baur, Leo H. B.
AU - Ansink, Tieneke J. M.
AU - Cozijnsen, Luc
AU - Pieper, Petronella G.
AU - Meijboom, Folkert J.
AU - Grobbee, Diederick E.
AU - Mulder, Barbara J. M.
PY - 2012
Y1 - 2012
N2 - Background: Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD). Methods: Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD. Results: Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart failure (26%) and sudden cardiac death (22%). Mortality was highest in the northern, most rural region of the country (p <= 0.05). Overall, death occurred out-of-hospital in approximately 35%, but more frequently in rural than in urban areas (55% versus 32%, p <= 0.05). Mortality was almost equally distributed throughout the seasons, although fall showed a slightly higher mortality rate. Cardiovascular death occurred suddenly in nearly 40%. Sudden cardiovascular death occurred in 8% during exercise, and most often out-of-hospital (62%). Of non-sudden cardiovascular deaths 18% had occurred out-of-hospital. Conclusion: In adult patients with congenital heart disease, mortality shows substantial regional and subtle seasonal variation. Death usually occurs at rest; approximately 1 of 10 sudden cardiovascular deaths occur during exercise. (C) 2010 Elsevier Ireland Ltd. All rights reserved
AB - Background: Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD). Methods: Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD. Results: Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart failure (26%) and sudden cardiac death (22%). Mortality was highest in the northern, most rural region of the country (p <= 0.05). Overall, death occurred out-of-hospital in approximately 35%, but more frequently in rural than in urban areas (55% versus 32%, p <= 0.05). Mortality was almost equally distributed throughout the seasons, although fall showed a slightly higher mortality rate. Cardiovascular death occurred suddenly in nearly 40%. Sudden cardiovascular death occurred in 8% during exercise, and most often out-of-hospital (62%). Of non-sudden cardiovascular deaths 18% had occurred out-of-hospital. Conclusion: In adult patients with congenital heart disease, mortality shows substantial regional and subtle seasonal variation. Death usually occurs at rest; approximately 1 of 10 sudden cardiovascular deaths occur during exercise. (C) 2010 Elsevier Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.ijcard.2010.09.015
DO - https://doi.org/10.1016/j.ijcard.2010.09.015
M3 - Article
C2 - 20934226
SN - 0167-5273
VL - 154
SP - 168
EP - 172
JO - International journal of cardiology
JF - International journal of cardiology
IS - 2
ER -