Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort

J.M. Rijkelijkhuizen; C.J. Girman; A. Mari; M.J. Alssema; T. Rhodes; M.G.A.A.M. Nijpels; P.J. Kostense; E.M.W. Eekhoff; P.P. Stein; R.J. Heine; J.M. Dekker

doi:https://doi.org/10.1016/j.diabres.2008.11.017

Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort

J.M. Rijkelijkhuizen, C.J. Girman, A. Mari, M.J. Alssema, T. Rhodes, M.G.A.A.M. Nijpels, P.J. Kostense, E.M.W. Eekhoff, P.P. Stein, R.J. Heine, J.M. Dekker

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Abstract

This study compared classical and model-based beta-cell responses during an oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) in a population-based cohort. Individuals with normal glucose metabolism (NGM, n=161), impaired glucose metabolism (IGM, n=19) and type 2 diabetes mellitus (DM, n=20) underwent a 75 g-OGTT and an MTT (75 g carbohydrates, 50 g fat, 24 g proteins). Classical estimates of beta-cell function (insulinogenic index and the ratio of areas under insulin and glucose curves) were calculated. Mathematical modelling was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. Insulin sensitivity was characterized by three surrogate estimates. Both classical and model-based estimates of beta-cell function were higher during MTT than during OGTT (P

Original language	Undefined/Unknown
Pages (from-to)	280-288
Journal	Diabetes Research and Clinical Practice
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/j.diabres.2008.11.017
Publication status	Published - 2009

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https://doi.org/10.1016/j.diabres.2008.11.017

Cite this

Rijkelijkhuizen, J. M., Girman, C. J., Mari, A., Alssema, M. J., Rhodes, T., Nijpels, M. G. A. A. M., Kostense, P. J., Eekhoff, E. M. W., Stein, P. P., Heine, R. J., & Dekker, J. M. (2009). Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort. Diabetes Research and Clinical Practice, 83(2), 280-288. https://doi.org/10.1016/j.diabres.2008.11.017

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abstract = "This study compared classical and model-based beta-cell responses during an oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) in a population-based cohort. Individuals with normal glucose metabolism (NGM, n=161), impaired glucose metabolism (IGM, n=19) and type 2 diabetes mellitus (DM, n=20) underwent a 75 g-OGTT and an MTT (75 g carbohydrates, 50 g fat, 24 g proteins). Classical estimates of beta-cell function (insulinogenic index and the ratio of areas under insulin and glucose curves) were calculated. Mathematical modelling was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. Insulin sensitivity was characterized by three surrogate estimates. Both classical and model-based estimates of beta-cell function were higher during MTT than during OGTT (P",

author = "J.M. Rijkelijkhuizen and C.J. Girman and A. Mari and M.J. Alssema and T. Rhodes and M.G.A.A.M. Nijpels and P.J. Kostense and E.M.W. Eekhoff and P.P. Stein and R.J. Heine and J.M. Dekker",

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Rijkelijkhuizen, JM, Girman, CJ, Mari, A, Alssema, MJ, Rhodes, T, Nijpels, MGAAM, Kostense, PJ, Eekhoff, EMW, Stein, PP, Heine, RJ & Dekker, JM 2009, 'Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort', Diabetes Research and Clinical Practice, vol. 83, no. 2, pp. 280-288. https://doi.org/10.1016/j.diabres.2008.11.017

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T1 - Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort

AU - Rijkelijkhuizen, J.M.

AU - Girman, C.J.

AU - Mari, A.

AU - Alssema, M.J.

AU - Rhodes, T.

AU - Nijpels, M.G.A.A.M.

AU - Kostense, P.J.

AU - Eekhoff, E.M.W.

AU - Stein, P.P.

AU - Heine, R.J.

AU - Dekker, J.M.

PY - 2009

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AB - This study compared classical and model-based beta-cell responses during an oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) in a population-based cohort. Individuals with normal glucose metabolism (NGM, n=161), impaired glucose metabolism (IGM, n=19) and type 2 diabetes mellitus (DM, n=20) underwent a 75 g-OGTT and an MTT (75 g carbohydrates, 50 g fat, 24 g proteins). Classical estimates of beta-cell function (insulinogenic index and the ratio of areas under insulin and glucose curves) were calculated. Mathematical modelling was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. Insulin sensitivity was characterized by three surrogate estimates. Both classical and model-based estimates of beta-cell function were higher during MTT than during OGTT (P

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DO - https://doi.org/10.1016/j.diabres.2008.11.017

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