Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

Khoa T. D. Thai; Hoang Lan Phuong; Tran Thi Thanh Nga; Phan Trong Giao; Le Quoc Hung; Nguyen van Nam; Tran Quang Binh; Cameron Simmons; Jeremy Farrar; Tran Thinh Hien; H. Rogier van Doorn; Menno D. de Jong; Peter J. de Vries

doi:https://doi.org/10.1016/j.jinf.2010.01.003

Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

Khoa T. D. Thai, Hoang Lan Phuong, Tran Thi Thanh Nga, Phan Trong Giao, Le Quoc Hung, Nguyen van Nam, Tran Quang Binh, Cameron Simmons, Jeremy Farrar, Tran Thinh Hien, H. Rogier van Doorn, Menno D. de Jong, Peter J. de Vries

Research output: Contribution to journal › Article › Academic › peer-review

42 Citations (Scopus)

Abstract

Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. Methods: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients. Results: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P = 0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P = 0.003) and DENV-4 (P <0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed. Conclusions: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	229-237
Journal	Journal of Infection
Volume	60
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2010.01.003
Publication status	Published - 2010

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https://doi.org/10.1016/j.jinf.2010.01.003

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Thai, K. T. D., Phuong, H. L., Thanh Nga, T. T., Giao, P. T., Hung, L. Q., van Nam, N., Binh, T. Q., Simmons, C., Farrar, J., Hien, T. T., Rogier van Doorn, H., de Jong, M. D., & de Vries, P. J. (2010). Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever. Journal of Infection, 60(3), 229-237. https://doi.org/10.1016/j.jinf.2010.01.003

@article{f2f40441cef74442b8900dfa5a03f856,

title = "Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever",

abstract = "Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. Methods: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients. Results: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P = 0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P = 0.003) and DENV-4 (P <0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed. Conclusions: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved",

author = "Thai, {Khoa T. D.} and Phuong, {Hoang Lan} and {Thanh Nga}, {Tran Thi} and Giao, {Phan Trong} and Hung, {Le Quoc} and {van Nam}, Nguyen and Binh, {Tran Quang} and Cameron Simmons and Jeremy Farrar and Hien, {Tran Thinh} and {Rogier van Doorn}, H. and {de Jong}, {Menno D.} and {de Vries}, {Peter J.}",

year = "2010",

doi = "https://doi.org/10.1016/j.jinf.2010.01.003",

language = "English",

volume = "60",

pages = "229--237",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "3",

}

Thai, KTD, Phuong, HL, Thanh Nga, TT, Giao, PT, Hung, LQ, van Nam, N, Binh, TQ, Simmons, C, Farrar, J, Hien, TT, Rogier van Doorn, H, de Jong, MD & de Vries, PJ 2010, 'Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever', Journal of Infection, vol. 60, no. 3, pp. 229-237. https://doi.org/10.1016/j.jinf.2010.01.003

Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever. / Thai, Khoa T. D.; Phuong, Hoang Lan; Thanh Nga, Tran Thi et al.
In: Journal of Infection, Vol. 60, No. 3, 2010, p. 229-237.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

AU - Thai, Khoa T. D.

AU - Phuong, Hoang Lan

AU - Thanh Nga, Tran Thi

AU - Giao, Phan Trong

AU - Hung, Le Quoc

AU - van Nam, Nguyen

AU - Binh, Tran Quang

AU - Simmons, Cameron

AU - Farrar, Jeremy

AU - Hien, Tran Thinh

AU - Rogier van Doorn, H.

AU - de Jong, Menno D.

AU - de Vries, Peter J.

PY - 2010

Y1 - 2010

N2 - Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. Methods: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients. Results: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P = 0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P = 0.003) and DENV-4 (P <0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed. Conclusions: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved

AB - Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. Methods: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients. Results: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P = 0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P = 0.003) and DENV-4 (P <0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed. Conclusions: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.jinf.2010.01.003

DO - https://doi.org/10.1016/j.jinf.2010.01.003

M3 - Article

C2 - 20080126

SN - 0163-4453

VL - 60

SP - 229

EP - 237

JO - Journal of Infection

JF - Journal of Infection

IS - 3

ER -