Clinical feasibility of combining intraoperative electron radiation therapy with minimally invasive surgery: a potential for electron-FLASH clinical development

Felipe Ángel Calvo Manuel, Javier Serrano, Claudio Solé, Mauricio Cambeiro, Jacobo Palma, Javier Aristu, Jose Luis Garcia-Sabrido, Miguel Angel Cuesta, Emilio del Valle, Fernando Lapuente, Bernardino Miñana, Miguel Ángel Morcillo, Jose Manuel Asencio, Javier Pascau

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Background: Local cancer therapy by combining real-time surgical exploration and resection with delivery of a single dose of high-energy electron irradiation entails a very precise and effective local therapeutic approach. Integrating the benefits from minimally invasive surgical techniques with the very precise delivery of intraoperative electron irradiation results in an efficient combined modality therapy. Methods: Patients with locally advanced disease, who are candidates for laparoscopic and/or thoracoscopic surgery, received an integrated multimodal management. Preoperative treatment included induction chemotherapy and/or chemoradiation, followed by laparoscopic surgery and intraoperative electron radiation therapy. Results: In a period of 5 consecutive years, 125 rectal cancer patients were treated, of which 35% underwent a laparoscopic approach. We found no differences in cancer outcomes and tolerance between the open and laparoscopic groups. Two esophageal cancer patients were treated with IOeRT during thoracoscopic resection, with the resection specimens showing intense downstaging effects. Two oligo-recurrent prostatic cancer patients (isolated nodal progression) had a robotic-assisted surgical resection and post-lymphadenectomy electron boost on the vascular and lateral pelvic wall. Conclusions: Minimally invasive and robotic-assisted surgery is feasible to combine with intraoperative electron radiation therapy and offers a new model explored with electron-FLASH beams.
Original languageEnglish
JournalClinical and Translational Oncology
Early online date2022
Publication statusE-pub ahead of print - 2022


  • Cancer surgery
  • Electron beams
  • Intraoperative radiation therapy
  • Laparoscopic surgery
  • Robotic surgery

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