TY - JOUR
T1 - Clinical features and risk factors associated with morbidity and mortality among patients with COVID-19 in northern Ethiopia
AU - Abraha, Hiluf Ebuy
AU - Gessesse, Zekarias
AU - Gebrecherkos, Teklay
AU - Kebede, Yazezew
AU - Weldegiargis, Aregawi Weldegebreal
AU - Tequare, Mengistu Hagazi
AU - Welderufael, Abadi Luel
AU - Zenebe, Dawit
AU - Gebremariam, Asqual Gebreslassie
AU - Dawit, Tsega Cherkos
AU - Gebremedhin, Daniel Woldu
AU - de Wit, Tobias Rinke
AU - Wolday, Dawit
N1 - Funding Information: This project was funded, in part, by the European and Developing Countries Clinical Trials Partnership (EDCTP) –European Union (Profile-Cov project, Grant #: RIA-2020EF-2095) . Funding Information: This project was funded, in part, by the European and Developing Countries Clinical Trials Partnership (EDCTP)?European Union (Profile-Cov project, Grant #: RIA-2020EF-2095). Publisher Copyright: © 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Objective: To describe the clinical features and assess the determinants of severity and in-hospital mortality of patients with coronavirus disease 2019 (COVID-19) from a unique setting in Ethiopia. Methods: Consecutive patients admitted to a COVID-19 isolation and treatment centre were included in this study. The overall clinical spectrum of COVID-19, and factors associated with risk of severe COVID-19 and in-hospital mortality were analysed. Results: Of 2617 quarantined patients, three-quarters (n = 1935, 74%) were asymptomatic and only 114 (4.4%) presented with severe COVID-19. Common characteristics among the 682 symptomatic patients were cough (n = 354, 50.6%), myalgia (n = 212, 31.1%), headache (n = 196, 28.7%), fever (n = 161, 23.6%), dyspnoea (n = 111, 16.3%), anosmia and/or dysgeusia (n = 90, 13.2%), sore throat (n = 87, 12.8%) and chest pain (n = 77, 11.3%). Factors associated with severe COVID-19 were older age [adjusted relative risk (aRR) 1.78, 95% confidence interval (CI) 1.61–1.97; P < 0.0001], diabetes (aRR 2.00, 95% CI 1.20–3.32; P = 0.007), cardiovascular disease (aRR 2.53, 95% CI 1.53–4.17; P < 0.0001), malignancy (aRR 4.57, 95% CI 1.62–12.87; P = 0.004), surgery/trauma (aRR 23.98, 95% CI 10.35–55.57; P < 0.0001) and human immunodeficiency virus infection (aRR 4.24, 95% CI 1.55–11.61; P = 005). Factors associated with risk of in-hospital mortality included older age (aRR 2.37, 95% CI 1.90–2.95; P < 0.001), malignancy (aRR 6.73, 95% CI 1.50–30.16; P = 0.013) and surgery/trauma (aRR 59.52, 95% CI 12.90–274.68; P < 0.0001). Conclusions: A significant proportion of cases of COVID-19 were asymptomatic, and key comorbid conditions increased the risk of severe COVID-19 and in-hospital mortality. These findings could help in the design of appropriate management strategies for patients.
AB - Objective: To describe the clinical features and assess the determinants of severity and in-hospital mortality of patients with coronavirus disease 2019 (COVID-19) from a unique setting in Ethiopia. Methods: Consecutive patients admitted to a COVID-19 isolation and treatment centre were included in this study. The overall clinical spectrum of COVID-19, and factors associated with risk of severe COVID-19 and in-hospital mortality were analysed. Results: Of 2617 quarantined patients, three-quarters (n = 1935, 74%) were asymptomatic and only 114 (4.4%) presented with severe COVID-19. Common characteristics among the 682 symptomatic patients were cough (n = 354, 50.6%), myalgia (n = 212, 31.1%), headache (n = 196, 28.7%), fever (n = 161, 23.6%), dyspnoea (n = 111, 16.3%), anosmia and/or dysgeusia (n = 90, 13.2%), sore throat (n = 87, 12.8%) and chest pain (n = 77, 11.3%). Factors associated with severe COVID-19 were older age [adjusted relative risk (aRR) 1.78, 95% confidence interval (CI) 1.61–1.97; P < 0.0001], diabetes (aRR 2.00, 95% CI 1.20–3.32; P = 0.007), cardiovascular disease (aRR 2.53, 95% CI 1.53–4.17; P < 0.0001), malignancy (aRR 4.57, 95% CI 1.62–12.87; P = 0.004), surgery/trauma (aRR 23.98, 95% CI 10.35–55.57; P < 0.0001) and human immunodeficiency virus infection (aRR 4.24, 95% CI 1.55–11.61; P = 005). Factors associated with risk of in-hospital mortality included older age (aRR 2.37, 95% CI 1.90–2.95; P < 0.001), malignancy (aRR 6.73, 95% CI 1.50–30.16; P = 0.013) and surgery/trauma (aRR 59.52, 95% CI 12.90–274.68; P < 0.0001). Conclusions: A significant proportion of cases of COVID-19 were asymptomatic, and key comorbid conditions increased the risk of severe COVID-19 and in-hospital mortality. These findings could help in the design of appropriate management strategies for patients.
KW - Africa
KW - COVID-19
KW - Clinical features
KW - Comorbidities
KW - Ethiopia
KW - Mortality
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85103987067&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijid.2021.03.037
DO - https://doi.org/10.1016/j.ijid.2021.03.037
M3 - Article
C2 - 33741488
SN - 1201-9712
VL - 105
SP - 776
EP - 783
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -