Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey

David McKeag; Carol Lane; John H. Lazarus; Lelio Baldeschi; Kostas Boboridis; A. Jane Dickinson; A. Iain Hullo; George Kahaly; Gerry Krassas; Claudio Marcocci; Michele Marinò; Maarten P. Mourits; Marco Nardi; Christopher Neoh; Jacques Orgiazzi; Petros Perros; Aldo Pinchera; Susanne Pitz; Mark F. Prummel; Maria S. Sartini; Wilmar M. Wiersinga

doi:https://doi.org/10.1136/bjo.2006.094607

Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey

David McKeag, Carol Lane, John H. Lazarus, Lelio Baldeschi, Kostas Boboridis, A. Jane Dickinson, A. Iain Hullo, George Kahaly, Gerry Krassas, Claudio Marcocci, Michele Marinò, Maarten P. Mourits, Marco Nardi, Christopher Neoh, Jacques Orgiazzi, Petros Perros, Aldo Pinchera, Susanne Pitz, Mark F. Prummel, Maria S. SartiniWilmar M. Wiersinga

Research output: Contribution to journal › Article › Academic › peer-review

239 Citations (Scopus)

Abstract

BACKGROUND: This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. METHODS: Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation were used. Each eye was classified as having definite, equivocal, or no DON. RESULTS: Graves' hyperthyroidism occurred in the majority; 20% had received radioiodine. Of 94 eyes, 55 had definite and 17 equivocal DON. Median Clinical Activity Score was 4/7 but 25% scored 3 or less, indicating severe inflammation was not essential. Best corrected visual acuity was 6/9 (Snellen) or worse in 75% of DON eyes. Colour vision was reduced in 33 eyes, of which all but one had DON. Half of the DON eyes had normal optic disc appearance. In DON eyes proptosis was > 21 mm (significant) in 66% and visual fields abnormal in 71%. Orbital imaging showed apical muscle crowding in 88% of DON patients. Optic nerve stretch and fat prolapse were infrequently reported. CONCLUSION: Patients with DON may not have severe proptosis and orbital inflammation. Optic disc swelling, impaired colour vision and radiological evidence of apical optic nerve compression are the most useful clinical features in this series

Original language	English
Pages (from-to)	455-458
Journal	British journal of ophthalmology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1136/bjo.2006.094607
Publication status	Published - 2007

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McKeag, D., Lane, C., Lazarus, J. H., Baldeschi, L., Boboridis, K., Dickinson, A. J., Hullo, A. I., Kahaly, G., Krassas, G., Marcocci, C., Marinò, M., Mourits, M. P., Nardi, M., Neoh, C., Orgiazzi, J., Perros, P., Pinchera, A., Pitz, S., Prummel, M. F., ... Wiersinga, W. M. (2007). Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey. British journal of ophthalmology, 91(4), 455-458. https://doi.org/10.1136/bjo.2006.094607

@article{555db5b204b0444fbf118ab6bcf47b89,

title = "Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey",

abstract = "BACKGROUND: This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. METHODS: Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation were used. Each eye was classified as having definite, equivocal, or no DON. RESULTS: Graves' hyperthyroidism occurred in the majority; 20% had received radioiodine. Of 94 eyes, 55 had definite and 17 equivocal DON. Median Clinical Activity Score was 4/7 but 25% scored 3 or less, indicating severe inflammation was not essential. Best corrected visual acuity was 6/9 (Snellen) or worse in 75% of DON eyes. Colour vision was reduced in 33 eyes, of which all but one had DON. Half of the DON eyes had normal optic disc appearance. In DON eyes proptosis was > 21 mm (significant) in 66% and visual fields abnormal in 71%. Orbital imaging showed apical muscle crowding in 88% of DON patients. Optic nerve stretch and fat prolapse were infrequently reported. CONCLUSION: Patients with DON may not have severe proptosis and orbital inflammation. Optic disc swelling, impaired colour vision and radiological evidence of apical optic nerve compression are the most useful clinical features in this series",

author = "David McKeag and Carol Lane and Lazarus, {John H.} and Lelio Baldeschi and Kostas Boboridis and Dickinson, {A. Jane} and Hullo, {A. Iain} and George Kahaly and Gerry Krassas and Claudio Marcocci and Michele Marin{\`o} and Mourits, {Maarten P.} and Marco Nardi and Christopher Neoh and Jacques Orgiazzi and Petros Perros and Aldo Pinchera and Susanne Pitz and Prummel, {Mark F.} and Sartini, {Maria S.} and Wiersinga, {Wilmar M.}",

year = "2007",

doi = "https://doi.org/10.1136/bjo.2006.094607",

language = "English",

volume = "91",

pages = "455--458",

journal = "British journal of ophthalmology",

issn = "0007-1161",

publisher = "BMJ Publishing Group",

number = "4",

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McKeag, D, Lane, C, Lazarus, JH, Baldeschi, L, Boboridis, K, Dickinson, AJ, Hullo, AI, Kahaly, G, Krassas, G, Marcocci, C, Marinò, M, Mourits, MP, Nardi, M, Neoh, C, Orgiazzi, J, Perros, P, Pinchera, A, Pitz, S, Prummel, MF, Sartini, MS & Wiersinga, WM 2007, 'Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey', British journal of ophthalmology, vol. 91, no. 4, pp. 455-458. https://doi.org/10.1136/bjo.2006.094607

TY - JOUR

T1 - Clinical features of dysthyroid optic neuropathy: a European Group on Graves' Orbitopathy (EUGOGO) survey

AU - McKeag, David

AU - Lane, Carol

AU - Lazarus, John H.

AU - Baldeschi, Lelio

AU - Boboridis, Kostas

AU - Dickinson, A. Jane

AU - Hullo, A. Iain

AU - Kahaly, George

AU - Krassas, Gerry

AU - Marcocci, Claudio

AU - Marinò, Michele

AU - Mourits, Maarten P.

AU - Nardi, Marco

AU - Neoh, Christopher

AU - Orgiazzi, Jacques

AU - Perros, Petros

AU - Pinchera, Aldo

AU - Pitz, Susanne

AU - Prummel, Mark F.

AU - Sartini, Maria S.

AU - Wiersinga, Wilmar M.

PY - 2007

Y1 - 2007

N2 - BACKGROUND: This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. METHODS: Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation were used. Each eye was classified as having definite, equivocal, or no DON. RESULTS: Graves' hyperthyroidism occurred in the majority; 20% had received radioiodine. Of 94 eyes, 55 had definite and 17 equivocal DON. Median Clinical Activity Score was 4/7 but 25% scored 3 or less, indicating severe inflammation was not essential. Best corrected visual acuity was 6/9 (Snellen) or worse in 75% of DON eyes. Colour vision was reduced in 33 eyes, of which all but one had DON. Half of the DON eyes had normal optic disc appearance. In DON eyes proptosis was > 21 mm (significant) in 66% and visual fields abnormal in 71%. Orbital imaging showed apical muscle crowding in 88% of DON patients. Optic nerve stretch and fat prolapse were infrequently reported. CONCLUSION: Patients with DON may not have severe proptosis and orbital inflammation. Optic disc swelling, impaired colour vision and radiological evidence of apical optic nerve compression are the most useful clinical features in this series

AB - BACKGROUND: This study was performed to determine clinical features of dysthyroid optic neuropathy (DON) across Europe. METHODS: Forty seven patients with DON presented to seven European centres during one year. Local protocols for thyroid status, ophthalmic examination and further investigation were used. Each eye was classified as having definite, equivocal, or no DON. RESULTS: Graves' hyperthyroidism occurred in the majority; 20% had received radioiodine. Of 94 eyes, 55 had definite and 17 equivocal DON. Median Clinical Activity Score was 4/7 but 25% scored 3 or less, indicating severe inflammation was not essential. Best corrected visual acuity was 6/9 (Snellen) or worse in 75% of DON eyes. Colour vision was reduced in 33 eyes, of which all but one had DON. Half of the DON eyes had normal optic disc appearance. In DON eyes proptosis was > 21 mm (significant) in 66% and visual fields abnormal in 71%. Orbital imaging showed apical muscle crowding in 88% of DON patients. Optic nerve stretch and fat prolapse were infrequently reported. CONCLUSION: Patients with DON may not have severe proptosis and orbital inflammation. Optic disc swelling, impaired colour vision and radiological evidence of apical optic nerve compression are the most useful clinical features in this series

U2 - https://doi.org/10.1136/bjo.2006.094607

DO - https://doi.org/10.1136/bjo.2006.094607

M3 - Article

C2 - 17035276

SN - 0007-1161

VL - 91

SP - 455

EP - 458

JO - British journal of ophthalmology

JF - British journal of ophthalmology

IS - 4

ER -