Abstract
OBJECTIVE: To identify and validate previously established phenotypes of knee osteoarthritis (OA) based on similarities in clinical patient characteristics.
METHODS: Knee OA patients (N = 551) from the Amsterdam OA (AMS-OA) cohort provided data. Four clinical patient characteristics were assessed: upper leg muscle strength, body mass index (BMI), radiographic severity (Kellgren/Lawrence [KL] grade), and depressive mood (the Hospital Anxiety and Depression Scale [HADS] questionnaire). Cluster analysis was performed to identify the optimal number of phenotypes. Differences in clinical characteristics between the phenotypes were analyzed with ANOVA.
RESULTS: Cluster analysis identified five phenotypes of knee OA patients: "minimal joint disease phenotype", "strong muscle strength phenotype", "severe radiographic OA phenotype", "obese phenotype", and "depressive mood phenotype".
CONCLUSIONS: Among patients with knee OA, five phenotypes were identified based on four clinical characteristics. To a high degree, the results are a replication of earlier findings in the OA Initiative, indicating that these five phenotypes seem a stable, valid, and clinically relevant finding.
Original language | English |
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Pages (from-to) | 544-549 |
Number of pages | 6 |
Journal | Osteoarthritis and cartilage |
Volume | 23 |
Issue number | 4 |
Early online date | 14 Jan 2015 |
DOIs | |
Publication status | Published - Apr 2015 |
Keywords
- Aged
- Body Mass Index
- Cluster Analysis
- Cohort Studies
- Comorbidity
- Cross-Sectional Studies
- Depression/psychology
- Female
- Humans
- Knee Joint/diagnostic imaging
- Male
- Middle Aged
- Muscle Strength/physiology
- Netherlands
- Obesity/complications
- Osteoarthritis, Knee/classification
- Phenotype
- Radiography
- Reproducibility of Results
- Severity of Illness Index
- Surveys and Questionnaires