TY - JOUR
T1 - Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
AU - Mohabati, Danial
AU - van Dijk, Elon H. C.
AU - van Rijssen, Thomas J.
AU - de Jong, Eiko K.
AU - Breukink, Myrte B.
AU - Martinez-Ciriano, Jose P.
AU - Dijkman, Greet
AU - Hoyng, Carel B.
AU - Fauser, Sascha
AU - Yzer, Suzanne
AU - Boon, Camiel J. F.
PY - 2018
Y1 - 2018
N2 - Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT). Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures. Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple “hot spots” of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit. Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.
AB - Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT). Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures. Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple “hot spots” of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit. Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057738783&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30498331
U2 - https://doi.org/10.2147/OPTH.S174573
DO - https://doi.org/10.2147/OPTH.S174573
M3 - Article
C2 - 30498331
SN - 1177-5467
VL - 12
SP - 2167
EP - 2176
JO - Clinical ophthalmology (Auckland, N.Z.)
JF - Clinical ophthalmology (Auckland, N.Z.)
ER -