TY - JOUR
T1 - Coagulation abnormalities in sepsis
T2 - Relation with inflammatory responses
AU - De Jonge, Evert
AU - Levi, Marcel
AU - Van Der Poll, Tom
PY - 2000
Y1 - 2000
N2 - Sepsis can be associated with profound alterations in the coagulation and fibrinolytic system. We discuss recent insights in the pathogenetic mechanisms of the activation of coagulation and focus on the relations of the coagulation, fibrinolytic, and inflammatory pathways. In addition, we address the role of natural inhibitors of coagulation like protein C, antithrombin, and tissue factor pathway inhibitor. Finally, we speculate on how these insights may translate into new treatment strategies for sepsis. (C) 2000 Lippincott Williams and Wilkins, Inc.
AB - Sepsis can be associated with profound alterations in the coagulation and fibrinolytic system. We discuss recent insights in the pathogenetic mechanisms of the activation of coagulation and focus on the relations of the coagulation, fibrinolytic, and inflammatory pathways. In addition, we address the role of natural inhibitors of coagulation like protein C, antithrombin, and tissue factor pathway inhibitor. Finally, we speculate on how these insights may translate into new treatment strategies for sepsis. (C) 2000 Lippincott Williams and Wilkins, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033820576&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/00075198-200010000-00003
DO - https://doi.org/10.1097/00075198-200010000-00003
M3 - Review article
SN - 1070-5295
VL - 6
SP - 317
EP - 322
JO - Current Opinion in Critical Care
JF - Current Opinion in Critical Care
IS - 5
ER -