TY - JOUR
T1 - Codiversification of gut microbiota with humans
AU - Suzuki, Taichi A.
AU - Fitzstevens, J. Liam
AU - Schmidt, Victor T.
AU - Enav, Hagay
AU - Huus, Kelsey E.
AU - Mbong Ngwese, Mirabeau
AU - Grießhammer, Anne
AU - Pfleiderer, Anne
AU - Adegbite, Bayode R.
AU - Zinsou, Jeannot F.
AU - Esen, Meral
AU - Velavan, Thirumalaisamy P.
AU - Adegnika, Ayola A.
AU - Song, Le Huu
AU - Spector, Timothy D.
AU - Muehlbauer, Amanda L.
AU - Marchi, Nina
AU - Kang, Hyena
AU - Maier, Lisa
AU - Blekhman, Ran
AU - Ségurel, Laure
AU - Ko, GwangPyo
AU - Youngblut, Nicholas D.
AU - Kremsner, Peter
AU - Ley, Ruth E.
N1 - Funding Information: We thank T. H. Nguyen, E. Cosgrove, A. Clark, A. Kostic, M. Taylor, Native American tribe officers (M. Bremer, J. Aguilar, J. Charlie, R. Williams, B. Lewis, S. Anton, A. Garcia-Lewis, and B. Bernstein), S. Dauser and members of the Department of Microbiome Science, and four anonymous reviewers. Funding: This work was supported by the Max Planck Society. T.D.S. was funded by the Wellcome Trust, Medical Research Council, European Union, Chronic Disease Research Foundation, Zoe Global Ltd., the National Institute for Health Research-funded BioResource, and the Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London. L.S. was supported by an Agence Nationale de la Recherche grant (MICROREGAL, ANR-15-CE02-0003). R.B. was supported by NIH grant R35-GM128716. Publisher Copyright: Copyright © 2022 The Authors.
PY - 2022/9/16
Y1 - 2022/9/16
N2 - The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.
AB - The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=85137880646&partnerID=8YFLogxK
U2 - https://doi.org/10.1126/science.abm7759
DO - https://doi.org/10.1126/science.abm7759
M3 - Article
C2 - 36108023
SN - 0036-8075
VL - 377
SP - 1328
EP - 1332
JO - Science
JF - Science
IS - 6612
ER -