TY - JOUR
T1 - Cognitive and motor functioning in gene carriers for Huntington's disease: A baseline study
AU - Witjes-Ané, Marie-Noëlle W.
AU - Vegter-van der Vlis, Maria
AU - van Vugt, Jeroen P. P.
AU - Lanser, Jan B. K.
AU - Hermans, Jo
AU - Zwinderman, Aeilko H.
AU - van Ommen, Gert-Jan B.
AU - Roos, Raymund A. C.
PY - 2003
Y1 - 2003
N2 - The aim of this study was to investigate the first changes in cognitive and motor functioning in Huntington's disease. Forty-six gene carriers, not clinically diagnosed for HD, were compared with 88 non-gene carriers. Gene carriers performed significantly worse on the Benton Visual Retention Test. This result was due to a minority of participants who had already developed cognitive impairment. Marginal differences appeared on the motor times of single reaction time measures after correction for motor signs. The findings are discussed in the context of inconsistencies in previous studies and underscore the need for longitudinal research
AB - The aim of this study was to investigate the first changes in cognitive and motor functioning in Huntington's disease. Forty-six gene carriers, not clinically diagnosed for HD, were compared with 88 non-gene carriers. Gene carriers performed significantly worse on the Benton Visual Retention Test. This result was due to a minority of participants who had already developed cognitive impairment. Marginal differences appeared on the motor times of single reaction time measures after correction for motor signs. The findings are discussed in the context of inconsistencies in previous studies and underscore the need for longitudinal research
U2 - https://doi.org/10.1176/appi.neuropsych.15.1.7
DO - https://doi.org/10.1176/appi.neuropsych.15.1.7
M3 - Article
C2 - 12556566
SN - 0895-0172
VL - 15
SP - 7
EP - 16
JO - Journal of neuropsychiatry and clinical neurosciences
JF - Journal of neuropsychiatry and clinical neurosciences
IS - 1
ER -