TY - JOUR
T1 - Cognitive functioning and mental health in mitochondrial disease: A systematic scoping review
AU - Klein, Inge-Lot
AU - van de Loo, Kim F. E.
AU - Smeitink, Jan A. M.
AU - Janssen, Mirian C. H.
AU - Kessels, Roy P. C.
AU - van Karnebeek, Clara D.
AU - van der Veer, Elja
AU - Custers, José A. E.
AU - Verhaak, Christianne M.
N1 - Funding Information: This research was partly funded by ‘ Prinses Beatrix Spierfonds ’, the Dutch foundation for muscular diseases, grant number “ W.OK17-06 ”. The funding body did not have a role in the study design; collection, analysis and interpretation of data; writing of the report; and in the decision to submit the article for publication. Publisher Copyright: © 2021 The Authors
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Mitochondrial diseases (MDs) are rare, heterogeneous, hereditary and progressive in nature. In addition to the serious somatic symptoms, patients with MD also experience problems regarding their cognitive functioning and mental health. We provide an overview of all published studies reporting on any aspect of cognitive functioning and/or mental health in patients with MD and their relatives. A total of 58 research articles and 45 case studies were included and critically reviewed. Cognitive impairments in multiple domains were reported. Mental disorders were frequently reported, especially depression and anxiety. Furthermore, most studies showed impairments in self-reported psychological functioning and high prevalence of mental health problems in (matrilineal) relatives. The included studies showed heterogeneity regarding patient samples, measurement instruments and reference groups, making comparisons cautious. Results highlight a high prevalence of cognitive impairments and mental disorders in patients with MD. Recommendations for further research as well as tailored patientcare with standardized follow-up are provided. Key gaps in the literature are identified, of which studies on natural history are of highest importance.
AB - Mitochondrial diseases (MDs) are rare, heterogeneous, hereditary and progressive in nature. In addition to the serious somatic symptoms, patients with MD also experience problems regarding their cognitive functioning and mental health. We provide an overview of all published studies reporting on any aspect of cognitive functioning and/or mental health in patients with MD and their relatives. A total of 58 research articles and 45 case studies were included and critically reviewed. Cognitive impairments in multiple domains were reported. Mental disorders were frequently reported, especially depression and anxiety. Furthermore, most studies showed impairments in self-reported psychological functioning and high prevalence of mental health problems in (matrilineal) relatives. The included studies showed heterogeneity regarding patient samples, measurement instruments and reference groups, making comparisons cautious. Results highlight a high prevalence of cognitive impairments and mental disorders in patients with MD. Recommendations for further research as well as tailored patientcare with standardized follow-up are provided. Key gaps in the literature are identified, of which studies on natural history are of highest importance.
KW - Cognitive functioning
KW - Fatigue
KW - Mental health
KW - Mitochondrial disease
KW - Psychiatry
KW - Psychology
KW - Scoping review
UR - http://www.scopus.com/inward/record.url?scp=85101391381&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neubiorev.2021.02.004
DO - https://doi.org/10.1016/j.neubiorev.2021.02.004
M3 - Review article
C2 - 33582231
SN - 0149-7634
VL - 125
SP - 57
EP - 77
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -