TY - JOUR
T1 - Cognitive Impairment in Patients with Cardiac Disease
T2 - Implications for Clinical Practice
AU - van Nieuwkerk, Astrid C.
AU - Delewi, Ronak
AU - Wolters, Frank J.
AU - Muller, Majon
AU - Daemen, Mat
AU - Biessels, Geert Jan
N1 - Funding Information: Dr Wolters was consultant for the PGGM pension fund (fees paid to institution) and received research grants from the Brain & Behavior Research Foundation, The Netherlands Organisation for Health Research and Development (ZonMw) and The Alzheimer’s Association, outside of the submitted work. Dr Biessels also receives research funding from The Netherlands Organisation for Health Research and Development (ZonMw), Vici grant 918.16.616. Dr Delewi received educational fees from Boston Scientific and Edwards Lifesciences. The other authors report no conflicts. Funding Information: We acknowledge support from The Netherlands CardioVascular Research Initiative: The Dutch Heart Foundation (CVON 2018-28 and 2012-06 Heart Brain Connection), Dutch Federation of University Medical Centres, The Netherlands Organisation for Health Research and Development, and The Royal Netherlands Academy of Sciences. Publisher Copyright: © 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Cognitive impairment is common in patients with cardiovascular disease. One in 3 patients presenting at cardiology clinics have some degree of cognitive impairment, depending on the cardiac condition, comorbidities, and age. In up to half of these cases cognitive impairment may go unrecognized; however, it may affect self-management and treatment adherence. The high prevalence of cognitive impairment in patients with cardiac disease is likely due to shared risk factors, as well as direct consequences of cardiac dysfunction on the brain. Moreover, cardiac interventions may have beneficial as well as adverse effects on cognitive functioning. In this review, we describe prevalence and risk factors for cognitive impairment in patients with several common cardiac conditions: heart failure, coronary artery disease, and aortic valve stenosis. We discuss the potential effects of guideline-based treatments on cognition and identify open questions and unmet needs. Given the high prevalence of unrecognized cognitive impairment in cardiac patients, we recommend a stepwise approach to improve detection and management of cognitive impairment.
AB - Cognitive impairment is common in patients with cardiovascular disease. One in 3 patients presenting at cardiology clinics have some degree of cognitive impairment, depending on the cardiac condition, comorbidities, and age. In up to half of these cases cognitive impairment may go unrecognized; however, it may affect self-management and treatment adherence. The high prevalence of cognitive impairment in patients with cardiac disease is likely due to shared risk factors, as well as direct consequences of cardiac dysfunction on the brain. Moreover, cardiac interventions may have beneficial as well as adverse effects on cognitive functioning. In this review, we describe prevalence and risk factors for cognitive impairment in patients with several common cardiac conditions: heart failure, coronary artery disease, and aortic valve stenosis. We discuss the potential effects of guideline-based treatments on cognition and identify open questions and unmet needs. Given the high prevalence of unrecognized cognitive impairment in cardiac patients, we recommend a stepwise approach to improve detection and management of cognitive impairment.
KW - aortic valve stenosis
KW - cardiovascular disease
KW - cognition
KW - cognitive dysfunction
KW - coronary artery disease
KW - heart failure
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85165751799&partnerID=8YFLogxK
U2 - https://doi.org/10.1161/STROKEAHA.123.040499
DO - https://doi.org/10.1161/STROKEAHA.123.040499
M3 - Review article
C2 - 37272393
SN - 0039-2499
VL - 54
SP - 2181
EP - 2191
JO - Stroke
JF - Stroke
IS - 8
ER -