Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

J. W. Mulder; P. M. Kruyt; M. Sewnath; J. Oosting; C. A. Seldenrijk; W. F. Weidema; G. J. Offerhaus; S. T. Pals

doi:https://doi.org/10.1016/S0140-6736(94)90290-9

Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

J. W. Mulder, P. M. Kruyt, M. Sewnath, J. Oosting, C. A. Seldenrijk, W. F. Weidema, G. J. Offerhaus, S. T. Pals

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

313 Citations (Scopus)

Abstract

CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients

Original language	English
Pages (from-to)	1470-1472
Journal	Lancet
Volume	344
Issue number	8935
DOIs	https://doi.org/10.1016/S0140-6736(94)90290-9
Publication status	Published - 1994

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https://doi.org/10.1016/S0140-6736(94)90290-9

Cite this

@article{f27e6abf93d34ef1845534c7edcf0830,

title = "Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins",

abstract = "CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients",

author = "Mulder, {J. W.} and Kruyt, {P. M.} and M. Sewnath and J. Oosting and Seldenrijk, {C. A.} and Weidema, {W. F.} and Offerhaus, {G. J.} and Pals, {S. T.}",

year = "1994",

doi = "https://doi.org/10.1016/S0140-6736(94)90290-9",

language = "English",

volume = "344",

pages = "1470--1472",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8935",

}

TY - JOUR

T1 - Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins

AU - Mulder, J. W.

AU - Kruyt, P. M.

AU - Sewnath, M.

AU - Oosting, J.

AU - Seldenrijk, C. A.

AU - Weidema, W. F.

AU - Offerhaus, G. J.

AU - Pals, S. T.

PY - 1994

Y1 - 1994

N2 - CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients

AB - CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients

U2 - https://doi.org/10.1016/S0140-6736(94)90290-9

DO - https://doi.org/10.1016/S0140-6736(94)90290-9

M3 - Comment/Letter to the editor

C2 - 7526103

SN - 0140-6736

VL - 344

SP - 1470

EP - 1472

JO - Lancet

JF - Lancet

IS - 8935

ER -