Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Chetan A. Patil; Nienke Bosschaart; Matthew D. Keller; Ton G. van Leeuwen; Anita Mahadevan-Jansen

doi:https://doi.org/10.1364/OL.33.001135

Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

Chetan A. Patil, Nienke Bosschaart, Matthew D. Keller, Ton G. van Leeuwen, Anita Mahadevan-Jansen

Research output: Contribution to journal › Article › Academic › peer-review

101 Citations (Scopus)

Abstract

We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab

Original language	English
Pages (from-to)	1135-1137
Journal	Optics Letters
Volume	33
Issue number	10
DOIs	https://doi.org/10.1364/OL.33.001135
Publication status	Published - 2008

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https://doi.org/10.1364/OL.33.001135

Cite this

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title = "Combined Raman spectroscopy and optical coherence tomography device for tissue characterization",

abstract = "We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab",

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T1 - Combined Raman spectroscopy and optical coherence tomography device for tissue characterization

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AU - Bosschaart, Nienke

AU - Keller, Matthew D.

AU - van Leeuwen, Ton G.

AU - Mahadevan-Jansen, Anita

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AB - We report a dual-modal device capable of sequential acquisition of Raman spectroscopy (RS) and optical coherence tomography (OCT) along a common optical axis. The device enhances application of both RS and OCT by precisely guiding RS acquisition with OCT images while also compensating for the lack of molecular specificity in OCT with the biochemical specificity of RS. We characterize the system performance and demonstrate the capability to identify structurally ambiguous features within an OCT image with RS in a scattering phantom, guide acquisition of RS from a localized malignancy in ex vivo breast tissue, and perform in vivo tissue analysis of a scab

U2 - https://doi.org/10.1364/OL.33.001135

DO - https://doi.org/10.1364/OL.33.001135

M3 - Article

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