TY - JOUR
T1 - Common brain disorders are associated with heritable patterns of apparent aging of the brain
AU - Karolinska Schizophrenia Project (KaSP)
AU - Kaufmann, Tobias
AU - van der Meer, Dennis
AU - Doan, Nhat Trung
AU - Schwarz, Emanuel
AU - Lund, Martina J.
AU - Agartz, Ingrid
AU - Alnæs, Dag
AU - Barch, Deanna M.
AU - Baur-Streubel, Ramona
AU - Bertolino, Alessandro
AU - Bettella, Francesco
AU - Beyer, Mona K.
AU - Bøen, Erlend
AU - Borgwardt, Stefan
AU - Brandt, Christine L.
AU - Buitelaar, Jan
AU - Celius, Elisabeth G.
AU - Cervenka, Simon
AU - Conzelmann, Annette
AU - Córdova-Palomera, Aldo
AU - Dale, Anders M.
AU - de Quervain, Dominique J. F.
AU - Carlo, PasqualeDi
AU - Djurovic, Srdjan
AU - Dørum, Erlend S.
AU - Eisenacher, Sarah
AU - Elvsåshagen, Torbjørn
AU - Espeseth, Thomas
AU - Fatouros-Bergman, Helena
AU - Flyckt, Lena
AU - Franke, Barbara
AU - Frei, Oleksandr
AU - Haatveit, Beathe
AU - Håberg, Asta K.
AU - Harbo, Hanne F.
AU - Hartman, Catharina A.
AU - Heslenfeld, Dirk
AU - Hoekstra, Pieter J.
AU - Høgestøl, Einar A.
AU - Jernigan, Terry L.
AU - Jonassen, Rune
AU - Jönsson, Erik G.
AU - Kirsch, Peter
AU - Kłoszewska, Iwona
AU - Kolskår, Knut K.
AU - Landrø, Nils Inge
AU - Hellard, StephanieLe
AU - Lesch, Klaus-Peter
AU - Lovestone, Simon
AU - Oosterlaan, Jaap
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
AB - Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072625058&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31551603
UR - http://www.scopus.com/inward/record.url?scp=85072625058&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41593-019-0471-7
DO - https://doi.org/10.1038/s41593-019-0471-7
M3 - Article
C2 - 31551603
SN - 1097-6256
VL - 22
SP - 1617
EP - 1623
JO - Nature neuroscience
JF - Nature neuroscience
IS - 10
ER -