Abstract
Original language | English |
---|---|
Pages (from-to) | 880-+ |
Journal | Nature Genetics |
Volume | 42 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2010 |
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In: Nature Genetics, Vol. 42, No. 10, 2010, p. 880-+.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Common variants at 19p13 are associated with susceptibility to ovarian cancer
AU - Bolton, Kelly L.
AU - Tyrer, Jonathan
AU - Song, Honglin
AU - Ramus, Susan J.
AU - Notaridou, Maria
AU - Jones, Chris
AU - Sher, Tanya
AU - Gentry-Maharaj, Aleksandra
AU - Wozniak, Eva
AU - Tsai, Ya-Yu
AU - Weidhaas, Joanne
AU - Paik, Daniel
AU - van den Berg, David J.
AU - Stram, Daniel O.
AU - Pearce, Celeste Leigh
AU - Wu, Anna H.
AU - Brewster, Wendy
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Narod, Steven A.
AU - Levine, Douglas A.
AU - Kaye, Stanley B.
AU - Brown, Robert
AU - Paul, Jim
AU - Flanagan, James
AU - Sieh, Weiva
AU - McGuire, Valerie
AU - Whittemore, Alice S.
AU - Campbell, Ian
AU - Gore, Martin E.
AU - Lissowska, Jolanta
AU - Yang, Hanna P.
AU - Medrek, Krzysztof
AU - Gronwald, Jacek
AU - Lubinski, Jan
AU - Jakubowska, Anna
AU - Le, Nhu D.
AU - Cook, Linda S.
AU - Kelemen, Linda E.
AU - Brooks-Wilson, Angela
AU - Brook-Wilson, Angela
AU - Massuger, Leon F. A. G.
AU - Kiemeney, Lambertus A.
AU - Aben, Katja K. H.
AU - van Altena, Anne M.
AU - Houlston, Richard
AU - Tomlinson, Ian
AU - Palmieri, Rachel T.
AU - Moorman, Patricia G.
AU - Schildkraut, Joellen
AU - Iversen, Edwin S.
AU - Phelan, Catherine
AU - Vierkant, Robert A.
AU - Cunningham, Julie M.
AU - Goode, Ellen L.
AU - Fridley, Brooke L.
AU - Kruger-Kjaer, Susan
AU - Blaeker, Jan
AU - Hogdall, Estrid
AU - Hogdall, Claus
AU - Gross, Jenny
AU - Karlan, Beth Y.
AU - Ness, Roberta B.
AU - Edwards, Robert P.
AU - Odunsi, Kunle
AU - Moyisch, Kirsten B.
AU - Baker, Julie A.
AU - Modugno, Francesmary
AU - Heikkinenen, Tuomas
AU - Butzow, Ralf
AU - Nevanlinna, Heli
AU - Leminen, Arto
AU - Bogdanova, Natalia
AU - Antonenkova, Natalia
AU - Doerk, Thilo
AU - Hillemanns, Peter
AU - Dürst, Matthias
AU - Runnebaum, Ingo
AU - Thompson, Pamela J.
AU - Carney, Michael E.
AU - Goodman, Marc T.
AU - Lurie, Galina
AU - Wang-Gohrke, Shan
AU - Hein, Rebecca
AU - Chang-Claude, Jenny
AU - Rossing, Mary Anne
AU - Cushing-Haugen, Kara L.
AU - Doherty, Jennifer
AU - Chen, Chu
AU - Rafnar, Thorunn
AU - Besenbacher, Soren
AU - Sulem, Patrick
AU - Stefansson, Kari
AU - Birrer, Michael J.
AU - Terry, Kathryn L.
AU - Hernandez, Dena
AU - Cramer, Daniel W.
AU - Vergote, Ignace
AU - Amant, Frederic
AU - Lambrechts, Diether
AU - Despierre, Evelyn
AU - Fasching, Peter A.
AU - Beckmann, Matthias W.
AU - Thiel, Falk C.
AU - Ekici, Arif B.
AU - Chen, Xiaoqing
AU - Johnatty, Sharon E.
AU - Webb, Penelope M.
AU - Beesley, Jonathan
AU - Chanock, Stephen
AU - Garcia-Closas, Montserrat
AU - Sellers, Tom
AU - Easton, Douglas F.
AU - Berchuck, Andrew
AU - Chenevix-Trench, Georgia
AU - Pharoah, Paul D. P.
AU - Gayther, Simon A.
PY - 2010
Y1 - 2010
N2 - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women(1). We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 x 10(-4) and P = 6 x 10(-4), respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 x 10(-9) and P = 4 x 10(-11), respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development
AB - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women(1). We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 x 10(-4) and P = 6 x 10(-4), respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 x 10(-9) and P = 4 x 10(-11), respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development
U2 - https://doi.org/10.1038/ng.666
DO - https://doi.org/10.1038/ng.666
M3 - Article
C2 - 20852633
SN - 1061-4036
VL - 42
SP - 880-+
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -