TY - JOUR
T1 - Comparative Connectomics
AU - van den Heuvel, Martijn P.
AU - Bullmore, Edward T.
AU - Sporns, Olaf
PY - 2016/5/1
Y1 - 2016/5/1
N2 - We introduce comparative connectomics, the quantitative study of cross-species commonalities and variations in brain network topology that aims to discover general principles of network architecture of nervous systems and the identification of species-specific features of brain connectivity. By comparing connectomes derived from simple to more advanced species, we identify two conserved themes of wiring: the tendency to organize network topology into communities that serve specialized functionality and the general drive to enable high topological integration by means of investment of neural resources in short communication paths, hubs, and rich clubs. Within the space of wiring possibilities that conform to these common principles, we argue that differences in connectome organization between closely related species support adaptations in cognition and behavior.
AB - We introduce comparative connectomics, the quantitative study of cross-species commonalities and variations in brain network topology that aims to discover general principles of network architecture of nervous systems and the identification of species-specific features of brain connectivity. By comparing connectomes derived from simple to more advanced species, we identify two conserved themes of wiring: the tendency to organize network topology into communities that serve specialized functionality and the general drive to enable high topological integration by means of investment of neural resources in short communication paths, hubs, and rich clubs. Within the space of wiring possibilities that conform to these common principles, we argue that differences in connectome organization between closely related species support adaptations in cognition and behavior.
UR - http://www.scopus.com/inward/record.url?scp=84961813432&partnerID=8YFLogxK
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U2 - https://doi.org/10.1016/j.tics.2016.03.001
DO - https://doi.org/10.1016/j.tics.2016.03.001
M3 - Review article
C2 - 27026480
SN - 1364-6613
VL - 20
SP - 345
EP - 361
JO - Trends in cognitive sciences
JF - Trends in cognitive sciences
IS - 5
ER -