Comparative Connectomics

Martijn P. van den Heuvel, Edward T. Bullmore, Olaf Sporns

Research output: Contribution to journalReview articleAcademicpeer-review

232 Citations (Scopus)


We introduce comparative connectomics, the quantitative study of cross-species commonalities and variations in brain network topology that aims to discover general principles of network architecture of nervous systems and the identification of species-specific features of brain connectivity. By comparing connectomes derived from simple to more advanced species, we identify two conserved themes of wiring: the tendency to organize network topology into communities that serve specialized functionality and the general drive to enable high topological integration by means of investment of neural resources in short communication paths, hubs, and rich clubs. Within the space of wiring possibilities that conform to these common principles, we argue that differences in connectome organization between closely related species support adaptations in cognition and behavior.

Original languageEnglish
Pages (from-to)345-361
Number of pages17
JournalTrends in cognitive sciences
Issue number5
Publication statusPublished - 1 May 2016

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