Comparison of HRRT and HR plus Scanners for Quantitative (R)-[C-11]verapamil, [C-11]raclopride and [C-11]flumazenil Brain Studies

F.H.P. van Velden, M.S.B. Mansor, D.M.E. van Assema, B.N.M. van Berckel, F.E. Froklage, S.N. Wang, R.C. Schuit, M.C. Asselin, A.A. Lammertsma, R. Boellaard, M.C. Huisman

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Purpose: This study was conducted to directly compare the high-resolution research tomograph (HRRT) (high-resolution brain) and HR+ (standard whole-body) positron emission tomography (PET) only scanners for quantitative brain studies using three tracers with vastly different tracer distributions.Procedures: Healthy volunteers underwent successive scans on HR+ and HRRT scanners (in random order) using either (R)-[11C]verapamil (n = 6), [11C]raclopride (n = 7) or [11C]flumazenil (n = 7). For all tracers, metabolite-corrected plasma-input functions were generated.Results: After resolution matching, HRRT-derived kinetic parameter values correlated well with those of HR+ for all tracers (intraclass correlation coefficients ≥0.78), having a good absolute interscanner test-retest variability (≤15 %). However, systematic differences can be seen for HRRT-derived kinetic parameter values (range −13 to +15 %).Conclusion: Quantification of kinetic parameters based on plasma-input models leads to comparable results when spatial resolution between HRRT and HR+ data is matched. When using reference-tissue models, differences remain that are likely caused by differences in attenuation and scatter corrections and/or image reconstruction.
Original languageEnglish
Pages (from-to)129-139
JournalMolecular Imaging and Biology
Issue number1
Publication statusPublished - 2015

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