Comparison of incidences of cardiovascular events among new users of different statins: a retrospective observational cohort study

E. M. Heintjes, F. J. Penning-van Beest, S. Johansson, A. F. Stalenhoef, R. M. Herings

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To compare incidences of cardiovascular disease (CVD) in general and myocardial infarction (MI) specifically between new users of different statins in daily practice. DESIGN AND METHODOLOGY: Retrospective observational cohort study. Data were obtained from the PHARMO Record Linkage System; the PHARMO database contains pharmacy dispensing records of 3 million patients in the Netherlands registered with community pharmacies, linked to hospitalisation records. The participants were new statin users in the period 2000-2005, excluding patients hospitalised for CVD events in the year prior to start of statin use. MAIN OUTCOME MEASURES: Adjusted hazard ratios of hospitalisations for CVD (including any type of ischemic heart disease, stroke, or revascularisation procedure) in general, or MI in particular, occurring during use of the initial statin within two years of start of therapy, comparing users of different statins. RESULTS: The mean follow-up duration of 76,147 new statin users (14,530 pravastatin, 27,752 simvastatin, 25,777 atorvastatin, 8088 rosuvastatin) was 55 weeks. Incidence rates of CVD and MI per 100 person years ranged from 0.75 and 0.15 for rosuvastatin to 1.72 and 0.29 for pravastatin. Rosuvastatin users had a lower incidence rate of CVD compared to other statin users in general (28% lower), and simvastatin (29% lower) and pravastatin users (40% lower) in particular. The difference with atorvastatin was not statistically significant. Since this was not a prospective randomised study, there is the potential for unobserved risk factors to be responsible for some of the differences observed. CONCLUSION: Compared to other statin users without recent prior cardiovascular events, the incidence of fatal and non-fatal CVD in this retrospective observational cohort study was 28% lower among rosuvastatin users.
Original languageEnglish
Pages (from-to)2621-2629
Number of pages9
JournalCurrent medical research and opinion
Volume25
Issue number11
DOIs
Publication statusPublished - 2009

Keywords

  • Adolescent Adult Aged Aged, 80 and over Anticholesteremic Agents/therapeutic use Cardiovascular Diseases/*epidemiology/etiology/prevention & control Cohort Studies Female Fluorobenzenes/therapeutic use Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use Hypercholesterolemia/complications/*drug therapy/epidemiology Incidence Male Middle Aged Netherlands/epidemiology Pyrimidines/therapeutic use Retrospective Studies Rosuvastatin Calcium Sulfonamides/therapeutic use Time Factors Young Adult

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