Abstract
BACKGROUND AND PURPOSE: Local hemodynamic information may help to stratify rupture risk of cerebral aneurysms. Patient-specific modeling of cerebral hemodynamics requires accurate data on BFV in perianeurysmal arteries as boundary conditions for CFD. The aim was to compare the BFV measured with PC-MR imaging with that obtained by using intra-arterial Doppler sonography and to determine interpatient variation in intracranial BFV. MATERIALS AND METHODS: In 10 patients with unruptured intracranial aneurysms, BFV was measured in the cavernous ICA with PC-MR imaging in conscious patients before treatment, and measured by using an intra-arterial Doppler sonography wire when the patient was anesthetized with either propofol 16 patients) or sevoflurane (4 patients). RESULTS: Both techniques identified a pulsatile blood flow pattern in cerebral arteries. PSV differed >50 cm/s between patients. A mean velocity of 41.3 cm/s 195% CI, 39.3-43.3) was measured with PC-MR imaging. With intra-arterial Doppler sonography, a mean velocity of 29.3 cm/s (95% CI, 25.8-32.8) was measured with the patient under propofol-based intravenous anesthesia. In patients under sevoflurane-based inhaled anesthesia, a mean velocity of 44.9 cm/s (95% CI, 40.6-49.3) was measured. CONCLUSIONS: We showed large differences in BFV between patients, emphasizing the importance of using patient-specific hemodynamic boundary conditions in CFD. PC-MR imaging measurements of BFV in conscious patients were comparable with those obtained with the intra-arterial Doppler sonography when the patient was anesthetized with a sevoflurane-based inhaled anesthetic
Original language | English |
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Pages (from-to) | 1786-1790 |
Number of pages | 5 |
Journal | AJNR. American journal of neuroradiology |
Volume | 33 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Adult
- Aged
- Blood Flow Velocity
- Cerebral Arteries/diagnostic imaging
- Cerebrovascular Circulation
- Female
- Humans
- Intracranial Aneurysm/diagnosis
- Magnetic Resonance Angiography/methods
- Male
- Middle Aged
- Reproducibility of Results
- Rheology/methods
- Sensitivity and Specificity
- Ultrasonography, Interventional/methods