TY - JOUR
T1 - Comparison of risk factors for the onset and maintenance of depression
AU - Bottomley, Christian
AU - Nazareth, Irwin
AU - Torres-González, Francisco
AU - Švab, Igor
AU - Maaroos, Heidi-Ingrid
AU - Geerlings, Mirjam I.
AU - Xavier, Miguel
AU - Saldivia, Sandra
AU - King, Michael
PY - 2010/1
Y1 - 2010/1
N2 - Background: Factors associated with depression are usually identified from cross-sectional studies. Aims: We explore the relative roles of onset and recovery in determining these associations. Method: Hazard ratios for onset and recovery were estimated for 39 risk factors from a cohort study of 10045 general practice attendees whose depression status was assessed at baseline, 6 and 12 months. Results: Risk factors have a stronger relative effect on the rate of onset than recovery. The strongest risk factors for both onset and maintenance of depression tend to be time-dependent. With the exception of female gender the strength of a risk factor's effect on onset is highly predictive of its impact on recovery. Conclusions: Preventive measures will achieve a greater reduction in the prevalence of depression than measures designed to eliminate risk factors post onset. The strength of time-dependent risk factors suggests that it is more productive to focus on proximal rather than distal factors.
AB - Background: Factors associated with depression are usually identified from cross-sectional studies. Aims: We explore the relative roles of onset and recovery in determining these associations. Method: Hazard ratios for onset and recovery were estimated for 39 risk factors from a cohort study of 10045 general practice attendees whose depression status was assessed at baseline, 6 and 12 months. Results: Risk factors have a stronger relative effect on the rate of onset than recovery. The strongest risk factors for both onset and maintenance of depression tend to be time-dependent. With the exception of female gender the strength of a risk factor's effect on onset is highly predictive of its impact on recovery. Conclusions: Preventive measures will achieve a greater reduction in the prevalence of depression than measures designed to eliminate risk factors post onset. The strength of time-dependent risk factors suggests that it is more productive to focus on proximal rather than distal factors.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=74949092749&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/20044653
U2 - https://doi.org/10.1192/bjp.bp.109.067116
DO - https://doi.org/10.1192/bjp.bp.109.067116
M3 - Article
C2 - 20044653
SN - 0007-1250
VL - 196
SP - 13
EP - 17
JO - British journal of psychiatry
JF - British journal of psychiatry
IS - 1
ER -