Complications of injectable agents used intraoperatively

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Interventions for making a diagnosis in the patient with chronic pain can present certain therapeutic challenges. The etiology and type of pain is not always clear and diagnostic or therapeutic blocks can be of value with injectable agents. Injectables given are steroids, local anesthetics, hyaluronacid, and neurolytic agents. Local anesthetics are safe, and complications due to use of local anesthetics are rare and depend on the skills of the practitioner performing any block, the correct indication and patient selection, anatomy, and pharmacology knowledge, as well as the technique and equipment used. Over the years, development of the use of neurolytic agents has become increasingly diverse: the combination of phenol and alcohol, application of glycerol, ammonium salts, hypertonic saline, and chlorocresol increasing the variety of neurolytic agents. A serious complication related to the administration of 50% alcohol following intraoperative celiac plexus injection resulted in permanent paraplegia.

Original languageEnglish
Title of host publicationComplications of Pain-Relieving Procedures
Subtitle of host publicationAn Illustrated Guide
Number of pages8
ISBN (Electronic)9781119757306
ISBN (Print)9781119757276
Publication statusPublished - 25 Aug 2022

Publication series

NameComplications of Pain-Relieving Procedures: An Illustrated Guide


  • Hyaluronacid
  • Injectable agents
  • Intraoperative celiac plexus injection
  • Local anesthetics
  • Neurolytic agents
  • Pain medicine
  • Steroids

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