Comprehensive geriatric assessment and transitional care in acutely hospitalized patients: the transitional care bridge randomized clinical trial

Bianca M. Buurman, Juliette L. Parlevliet, Heather G. Allore, Willem Blok, Bob A.J. van Deelen, Eric P. Moll van Charante, Rob J. de Haan, Sophia E. de Rooij

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IMPORTANCE: Older adults acutely hospitalized are at risk of disability. Trials on comprehensive geriatric assessment (CGA) and transitional care present inconsistent results.

OBJECTIVE: To test whether an intervention of systematic CGA, followed by the transitional care bridge program, improved activities of daily living (ADLs) compared with systematic CGA alone.

DESIGN, SETTING, AND PARTICIPANTS: This study was a double-blind, multicenter, randomized clinical trial conducted at 3 hospitals with affiliated home care organizations in the Netherlands between September 1, 2010, and March 1, 2014. In total, 1070 consecutive patients were eligible, 674 (63.0%) of whom enrolled. They were 65 years or older, acutely hospitalized to a medical ward for at least 48 hours with an Identification of Seniors at Risk-Hospitalized Patients score of 2 or higher, and randomized using permuted blocks stratified by study site and Mini-Mental State Examination score (<24 vs ≥24). The dates of the analysis were June 1, 2014, to November 15, 2014.

INTERVENTIONS: The transitional care bridge program intervention was started during hospitalization by a visit from a community care registered nurse (CCRN) and continued after discharge with home visits at 2 days and at 2, 6, 12, and 24 weeks. The CCRNs applied the CGA care and treatment plan.

MAIN OUTCOMES AND MEASURES: The main outcome was the Katz Index of ADL at 6 months compared with 2 weeks before admission. Secondary outcomes were mortality, cognitive functioning, time to hospital readmission, and the time to discharge from a nursing home.

RESULTS: The study cohort comprised 674 participants. Their mean age was 80 years, 42.1% (n = 284) were male, and 39.2% (n = 264) were cognitively impaired at admission. Intent-to-treat analysis found no differences in the mean Katz Index of ADL at 6 months between the intervention arm (mean, 2.0; 95% CI, 1.8-2.2) and the CGA-only arm (mean, 1.9; 95% CI, 1.7-2.2). For secondary outcomes, there were 85 deaths (25.2%) in the intervention arm and 104 deaths (30.9%) in the CGA-only arm, resulting in a lower risk on the time to death within 6 months after hospital admission (hazard ratio, 0.75; 95% CI, 0.56-0.99; P = .045; number needed to treat to prevent 1 death, 16). No other secondary outcome was significant.

CONCLUSIONS AND RELEVANCE: A systematic CGA, followed by the transitional care bridge program, showed no effect on ADL functioning in acutely hospitalized older patients.

TRIAL REGISTRATION: Netherlands Trial Registry: NTR2384.

Original languageEnglish
Pages (from-to)302-309
Number of pages8
JournalJama internal medicine
Issue number3
Publication statusPublished - Mar 2016


  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Cognition
  • Comparative Study
  • Double-Blind Method
  • Female
  • Geriatric Assessment
  • Home Care Services
  • Homes for the Aged
  • Humans
  • Journal Article
  • Male
  • Mortality
  • Multicenter Study
  • Netherlands
  • Nursing Homes
  • Patient Care Planning
  • Patient Discharge
  • Patient Readmission
  • Patient Selection
  • Program Evaluation
  • Proportional Hazards Models
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Transitional Care

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