COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome

Erik Boot; Jan Booij; Janneke R. Zinkstok; Frank Baas; Ann Swillen; Michael J. Owen; Declan G. Murphy; Kieran C. Murphy; Don H. Linszen; Thérèse A. van Amelsvoort

doi:https://doi.org/10.1002/syn.20932

COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome

Erik Boot, Jan Booij, Janneke R. Zinkstok, Frank Baas, Ann Swillen, Michael J. Owen, Declan G. Murphy, Kieran C. Murphy, Don H. Linszen, Thérèse A. van Amelsvoort

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Abstract

Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders

Original language	English
Pages (from-to)	967-970
Journal	Synapse (New York, N.Y.)
Volume	65
Issue number	9
DOIs	https://doi.org/10.1002/syn.20932
Publication status	Published - 2011

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@article{6b1a336270004d98a9c9fafe45154464,

title = "COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome",

abstract = "Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders",

author = "Erik Boot and Jan Booij and Zinkstok, {Janneke R.} and Frank Baas and Ann Swillen and Owen, {Michael J.} and Murphy, {Declan G.} and Murphy, {Kieran C.} and Linszen, {Don H.} and {van Amelsvoort}, {Th{\'e}r{\`e}se A.}",

year = "2011",

doi = "https://doi.org/10.1002/syn.20932",

language = "English",

volume = "65",

pages = "967--970",

journal = "Synapse (New York, N.Y.)",

issn = "0887-4476",

publisher = "Wiley-Liss Inc.",

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TY - JOUR

T1 - COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome

AU - Boot, Erik

AU - Booij, Jan

AU - Zinkstok, Janneke R.

AU - Baas, Frank

AU - Swillen, Ann

AU - Owen, Michael J.

AU - Murphy, Declan G.

AU - Murphy, Kieran C.

AU - Linszen, Don H.

AU - van Amelsvoort, Thérèse A.

PY - 2011

Y1 - 2011

N2 - Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders

AB - Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2/3) R binding ratios (D(2/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders

U2 - https://doi.org/10.1002/syn.20932

DO - https://doi.org/10.1002/syn.20932

M3 - Article

C2 - 21465565

SN - 0887-4476

VL - 65

SP - 967

EP - 970

JO - Synapse (New York, N.Y.)

JF - Synapse (New York, N.Y.)

IS - 9

ER -