Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease

W. A. van Gool; M. A. Kuiper; G. J. Walstra; E. C. Wolters; P. A. Bolhuis

doi:https://doi.org/10.1002/ana.410370221

Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease

W. A. van Gool, M. A. Kuiper, G. J. Walstra, E. C. Wolters, P. A. Bolhuis

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Abstract

Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease

Original language	English
Pages (from-to)	277-279
Journal	Annals of neurology
Volume	37
Issue number	2
DOIs	https://doi.org/10.1002/ana.410370221
Publication status	Published - 1995

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https://doi.org/10.1002/ana.410370221

Cite this

@article{1e47488bcf0446e5a6b922c3a6df8db2,

title = "Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease",

abstract = "Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease",

author = "{van Gool}, {W. A.} and Kuiper, {M. A.} and Walstra, {G. J.} and Wolters, {E. C.} and Bolhuis, {P. A.}",

year = "1995",

doi = "https://doi.org/10.1002/ana.410370221",

language = "English",

volume = "37",

pages = "277--279",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "2",

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TY - JOUR

T1 - Concentrations of amyloid beta protein in cerebrospinal fluid of patients with Alzheimer's disease

AU - van Gool, W. A.

AU - Kuiper, M. A.

AU - Walstra, G. J.

AU - Wolters, E. C.

AU - Bolhuis, P. A.

PY - 1995

Y1 - 1995

N2 - Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease

AB - Deposition of fibrillar amyloid beta protein (A beta) is increased in brains of patients with Alzheimer's disease. Concentrations of A beta were measured in cerebrospinal fluid with an enzyme-linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of A beta in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble A beta in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated A beta in the brain of patients with Alzheimer's disease

U2 - https://doi.org/10.1002/ana.410370221

DO - https://doi.org/10.1002/ana.410370221

M3 - Comment/Letter to the editor

C2 - 7847870

SN - 0364-5134

VL - 37

SP - 277

EP - 279

JO - Annals of neurology

JF - Annals of neurology

IS - 2

ER -