TY - JOUR
T1 - Consensus definitions in imported human schistosomiasis
T2 - a GeoSentinel and TropNet Delphi study
AU - Tamarozzi, Francesca
AU - Mazzi, Cristina
AU - Antinori, Spinello
AU - Arsuaga, Marta
AU - Becker, S. ren L.
AU - Bottieau, Emmanuel
AU - Camprubi-Ferrer, Daniel
AU - Caumes, Eric
AU - Duvignaud, Alexandre
AU - Grobusch, Martin P.
AU - Jaureguiberry, Stephane
AU - Jordan, Sabine
AU - Mueller, Andreas
AU - Neumayr, Andreas
AU - Perez-Molina, Jose A.
AU - Salas-Coronas, Joaquin
AU - Salvador, Fernando
AU - Tomasoni, Lina R.
AU - van Hellemond, Jaap J.
AU - Vaughan, Stephen D.
AU - Wammes, Linda J.
AU - Zammarchi, Lorenzo
AU - Buonfrate, Dora
AU - Huits, Ralph
AU - van Lieshout, Lisette
AU - Gobbi, Federico
N1 - Publisher Copyright: © 2024 Elsevier Ltd
PY - 2024
Y1 - 2024
N2 - Terminology in schistosomiasis is not harmonised, generating misunderstanding in data interpretation and clinical descriptions. This study aimed to achieve consensus on definitions of clinical aspects of schistosomiasis in migrants and returning travellers. We applied the Delphi method. Experts from institutions affiliated with GeoSentinel and TropNet, identified through clinical and scientific criteria, were invited to participate. Five external reviewers revised and pilot-tested the statements. Statements focusing on the definitions of acute or chronic; possible, probable, or confirmed; active; and complicated schistosomiasis were managed through REDCap and replies managed in a blinded manner. Round 1 mapped the definitions used by experts; subsequent rounds were done to reach consensus, or quantify disagreement, on the proposed statements. Data were analysed with percentages, medians, and IQRs of a 5-point Likert scale. The study was terminated on the basis of consensus or stability-related and time-related criteria. 28 clinicians and scientists met the criteria for experts. 25 (89%) of 28 experts replied to Round 1, 18 (64%) of 28 to Round 2, 19 (68%) of 28 to Round 3, and 21 (75%) of 28 to at least two rounds. High-level consensus (79–100% agreement and IQRs ≤1) was reached for all definitions. Consensus definitions will foster harmonised scientific and clinical communication and support future research and development of management guidelines for schistosomiasis.
AB - Terminology in schistosomiasis is not harmonised, generating misunderstanding in data interpretation and clinical descriptions. This study aimed to achieve consensus on definitions of clinical aspects of schistosomiasis in migrants and returning travellers. We applied the Delphi method. Experts from institutions affiliated with GeoSentinel and TropNet, identified through clinical and scientific criteria, were invited to participate. Five external reviewers revised and pilot-tested the statements. Statements focusing on the definitions of acute or chronic; possible, probable, or confirmed; active; and complicated schistosomiasis were managed through REDCap and replies managed in a blinded manner. Round 1 mapped the definitions used by experts; subsequent rounds were done to reach consensus, or quantify disagreement, on the proposed statements. Data were analysed with percentages, medians, and IQRs of a 5-point Likert scale. The study was terminated on the basis of consensus or stability-related and time-related criteria. 28 clinicians and scientists met the criteria for experts. 25 (89%) of 28 experts replied to Round 1, 18 (64%) of 28 to Round 2, 19 (68%) of 28 to Round 3, and 21 (75%) of 28 to at least two rounds. High-level consensus (79–100% agreement and IQRs ≤1) was reached for all definitions. Consensus definitions will foster harmonised scientific and clinical communication and support future research and development of management guidelines for schistosomiasis.
UR - http://www.scopus.com/inward/record.url?scp=85187565916&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(24)00080-X
DO - 10.1016/S1473-3099(24)00080-X
M3 - Review article
C2 - 38467128
SN - 1473-3099
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
ER -