TY - JOUR
T1 - Consensus-driven conceptual development of a standardized whole body-MRI scoring system for assessment of disease activity in juvenile idiopathic arthritis: MRI in JIA OMERACT working group
AU - Panwar, Jyoti
AU - Tolend, Mirkamal
AU - Redd, Bernadette
AU - Srinivasalu, Hemalatha
AU - Colbert, Robert A.
AU - Akikusa, Jonathan
AU - Appenzeller, Simone
AU - Carrino, John A.
AU - Herregods, Nele
AU - Jans, Lennart
AU - Highmore, Kerri
AU - von Kalle, Thekla
AU - Kirkhus, Eva
AU - Rumsey, Dax G.
AU - Jaremko, Jacob L.
AU - Clemente, Inarejos Emilio J.
AU - van Rossum, Marion A.
AU - Stimec, Jennifer
AU - Tse, Shirley M.
AU - Twilt, Marinka
AU - Tzaribachev, Nikolay
AU - Sudol-Szopinska, Iwona
AU - Meyers, Arthur B.
AU - Doria, Andrea S.
N1 - Funding Information: Robert A. Colbert and Hemalatha Srinivasalu were supported by the NIAMS Intramural Research Program Grant Z01-AR-041184 . Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021/12
Y1 - 2021/12
N2 - Objectives: Whole body-MRI is helpful in directing diagnostic and treatment approaches, and as a research outcome measure. We describe our initial consensus-driven phase towards developing a whole body-MRI scoring system for juvenile idiopathic arthritis. Methods: An iterative approach using three rounds of anonymous Delphi surveys followed by a consensus meeting was used to draft the structure of the whole body-MRI scoring system, including the relevant anatomic joints and entheses for assessment, diagnostic item selection, definition and grading, and selection of appropriate MRI planes and sequences. The surveys were completed independently by an international expert group consisting of pediatric radiologists and rheumatologists. Results: Twenty-two experts participated in at least one of three rounds of Delphi surveys and a concluding consensus meeting. A first iteration scoring system was developed which ultimately included the assessment of 100 peripheral, 23 chest, and 76 axial joints, and 64 entheses, with 2–4 diagnostic items graded in each of the items, using binary (presence/absence) and 2-3-level ordinal scores. Recommendations on anatomic MRI planes and sequences were specified as the minimally necessary imaging protocol for the scoring system. Conclusion: A novel whole body-MRI scoring system for juvenile idiopathic arthritis was developed by consensus among members of MRI in JIA OMERACT working group. Further iterative refinements, reliability testing, and responsiveness are warranted in upcoming studies.
AB - Objectives: Whole body-MRI is helpful in directing diagnostic and treatment approaches, and as a research outcome measure. We describe our initial consensus-driven phase towards developing a whole body-MRI scoring system for juvenile idiopathic arthritis. Methods: An iterative approach using three rounds of anonymous Delphi surveys followed by a consensus meeting was used to draft the structure of the whole body-MRI scoring system, including the relevant anatomic joints and entheses for assessment, diagnostic item selection, definition and grading, and selection of appropriate MRI planes and sequences. The surveys were completed independently by an international expert group consisting of pediatric radiologists and rheumatologists. Results: Twenty-two experts participated in at least one of three rounds of Delphi surveys and a concluding consensus meeting. A first iteration scoring system was developed which ultimately included the assessment of 100 peripheral, 23 chest, and 76 axial joints, and 64 entheses, with 2–4 diagnostic items graded in each of the items, using binary (presence/absence) and 2-3-level ordinal scores. Recommendations on anatomic MRI planes and sequences were specified as the minimally necessary imaging protocol for the scoring system. Conclusion: A novel whole body-MRI scoring system for juvenile idiopathic arthritis was developed by consensus among members of MRI in JIA OMERACT working group. Further iterative refinements, reliability testing, and responsiveness are warranted in upcoming studies.
KW - Adolescents
KW - Children
KW - Enthesitis-related arthritis
KW - Juvenile idiopathic arthritis
KW - Scoring system
KW - Spondyloarthropathy
KW - Whole body-MRI
UR - http://www.scopus.com/inward/record.url?scp=85113837403&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.semarthrit.2021.07.017
DO - https://doi.org/10.1016/j.semarthrit.2021.07.017
M3 - Article
C2 - 34465447
SN - 0049-0172
VL - 51
SP - 1350
EP - 1359
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 6
ER -