TY - JOUR
T1 - Consistency of a high-grade dysplasia diagnosis in Barrett's oesophagus: A Dutch nationwide cohort study
AU - Verbeek, Romy E.
AU - van Oijen, Martijn G. H.
AU - ten Kate, Fiebo J.
AU - Vleggaar, Frank P.
AU - van Baal, Jantine W. P. M.
AU - Siersema, Peter D.
PY - 2014
Y1 - 2014
N2 - Background: Consistency of high-grade dysplasia in Barrett's oesophagus is incompletely known and the clinical course may vary between patients. Aims: To evaluate the consistency of high-grade dysplasia diagnosis in a Dutch nationwide cohort and to identify predictors for (re-) detecting high-grade dysplasia or oesophageal adenocarcinoma when >= 1 follow-up evaluations after an initial high-grade dysplasia diagnosis were scored with a lower histological grade. Methods: In this retrospective cohort study, all patients diagnosed with high-grade dysplasia in Barrett's oesophagus between 1999 and 2008 in the Netherlands were selected using the nationwide histopathology registry. Multivariate analysis was performed to identify predictors for (re-) detecting high-grade dysplasia or oesophageal adenocarcinoma in patients with >= 1 follow-up evaluations scored with a lower grade. Results: In total, 512 high-grade dysplasia patients were included, of whom 53% had >= 1 follow-up evaluations scored with a lower grade. The (re-) detection risk was increased when follow-up was performed in a university hospital and when endoscopic/surgical resection was performed and decreased with an increasing number of follow-up evaluations scored with a lower grade. Conclusion: High-grade dysplasia diagnosis was inconsistent in more than half of patients. (Endoscopic) resection in an expert centre is recommended to (re-) detect high-grade dysplasia or oesophageal adenocarcinoma when an endoscopic follow-up protocol with biopsies repeatedly shows a lower histological grade. (C) 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved
AB - Background: Consistency of high-grade dysplasia in Barrett's oesophagus is incompletely known and the clinical course may vary between patients. Aims: To evaluate the consistency of high-grade dysplasia diagnosis in a Dutch nationwide cohort and to identify predictors for (re-) detecting high-grade dysplasia or oesophageal adenocarcinoma when >= 1 follow-up evaluations after an initial high-grade dysplasia diagnosis were scored with a lower histological grade. Methods: In this retrospective cohort study, all patients diagnosed with high-grade dysplasia in Barrett's oesophagus between 1999 and 2008 in the Netherlands were selected using the nationwide histopathology registry. Multivariate analysis was performed to identify predictors for (re-) detecting high-grade dysplasia or oesophageal adenocarcinoma in patients with >= 1 follow-up evaluations scored with a lower grade. Results: In total, 512 high-grade dysplasia patients were included, of whom 53% had >= 1 follow-up evaluations scored with a lower grade. The (re-) detection risk was increased when follow-up was performed in a university hospital and when endoscopic/surgical resection was performed and decreased with an increasing number of follow-up evaluations scored with a lower grade. Conclusion: High-grade dysplasia diagnosis was inconsistent in more than half of patients. (Endoscopic) resection in an expert centre is recommended to (re-) detect high-grade dysplasia or oesophageal adenocarcinoma when an endoscopic follow-up protocol with biopsies repeatedly shows a lower histological grade. (C) 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.dld.2013.11.010
DO - https://doi.org/10.1016/j.dld.2013.11.010
M3 - Article
C2 - 24388501
SN - 1590-8658
VL - 46
SP - 318
EP - 322
JO - Digestive and liver disease
JF - Digestive and liver disease
IS - 4
ER -